Anti-Mouse CXCL16 Antibody (12-81)
Based on 1 Customer Validation
Anti-Mouse CXCL16 Antibody (12-81) is an antibody targeting mouse CXCL16. Anti-Mouse CXCL16 Antibody (12-81) blocks the CXCL16/CXCR6 signaling axis. Anti-Mouse CXCL16 Antibody (12-81) reduces the recruitment of CD8+ T cells into the brain. Anti-Mouse CXCL16 Antibody (12-81) alleviates the reduction of hippocampal neurogenesis. Anti-Mouse CXCL16 Antibody (12-81) attenuates anxiety-like behaviors in mice. Anti-Mouse CXCL16 Antibody (12-81) can be used in studies related to anxiety-like behaviors. The recommended isotype control is Rat IgG1 kappa, Isotype Control (HY-P99979).
For research use only. We do not sell to patients.
- Purity : 97.425%
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
[1]|
CXCL16 |
CXCR6 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (male, 4-6 weeks old, hepatitis B vaccine-induced neuroinflammation and anxiety model)[1]
-
Dosage:4 μL per injection
-
Administration:i.c.v.; two injections (first left lateral ventricle, second right lateral ventricle on Day 7)
-
Result:Reduced CD8+ T cell recruitment to the brain ventricles compared to IgG1 controls.
Increased number of Ki67+ and DCX+/Ki67+ newborn neurons in the hippocampal dentate gyrus relative to HBV + IgG1 controls.
Increased total travel distance, duration in the central area, and number of entries into the central area in the open-field test compared to HBV + IgG1 controls.
Increased time spent and travel distance in the open arms in the elevated plus maze test compared to HBV + IgG1 controls.
Gene ID
Accession
Q8BSU2
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
in vivo neutralization of CXCL16; in vitro neutralization of CXCL16; Functional assay; Flow cytometr
Chemical Information
-
Appearance Liquid
-
Color Colorless to light yellow
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
SH-SY5Y neuronal-like differentiation
SH-SY5Y neuronal-like differentiation uses defined culture conditions to shift proliferative human neuroblastoma cells toward a neuron-like state, mainly assessed by reduced proliferation, neurite extension, neuronal-marker expression, and, in some protocols, increased dependence on neurotrophic support. Retinoic acid (RA) is commonly used for the first differentiation phase, and sequential RA followed by brain-derived neurotrophic factor (BDNF) in serum-free medium is a well-characterized approach for generating neuron-like SH-SY5Y cultures with extensive neurite outgrowth. The primary readouts are morphology-based neurite outgrowth and marker-based confirmation using proteins such as βIII-tubulin, MAP2, GAP43, synaptophysin, NeuN, NSE, TH, or related neuronal/synaptic markers, depending on the study endpoint.
-
Cell differentiation
Cell differentiation refers to the process in which cells of the same origin gradually produce cell groups with different morphological structure and functional characteristics.
Purity & Documentation
-
Data Sheet (259 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CXCL16 Antibody (12-81) Related Classifications
HY-P991752 Related Classifications
Powered by Bioz