TNPO3 Antibody (YA1986)
(Synonyms: TNPO 3; Imp12; Importin 12; IPO12; MTR10A; TNPO3; Transportin 3; Transportin SR; TRN-SR2; TRNSR)
Based on 1 Customer Validation
TNPO3 Antibody (YA1986) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNPO3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 |
Product Details
TNPO3 Antibody (YA1986) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNPO3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 104 kDa
Entrez Gene: 23534 Human ; 320938 Mouse ; 296954 Rat
SwissProt: Q9Y5L0 Human ; Q6P2B1 Mouse ;
OMIM: 608423 Human
A synthesized peptide derived from human TNPO3 aa870-923/923.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TNPO3 is an Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus; (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration[1][2][3][4][5][6][7][8][9][10][11][12].
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Subcellular Localization
Nucleus envelope; Cytoplasm
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Expression
Tissue_specificity:Expressed in skeletal muscle -
Isoforms & Post-Translational Modification
Q9Y5L0 has 4 isomers: Q9Y5L0-2: 104203 Da (predicted); Q9Y5L0-1: 108001 Da (predicted); Q9Y5L0-3: 102541 Da (predicted); Q9Y5L0-5: 97372 Da (predicted).
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Subunit
Interacts with (GTP-bound) Ran (PubMed:23878195, PubMed:24449914, PubMed:24915079). Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import (PubMed:10366588, PubMed:10713112, PubMed:11517331). Interacts with NUP62 (PubMed:11517331, PubMed:24449914). Interacts with RBM4 (PubMed:12628928). Interacts with CPSF6, promoting its nuclear import (PubMed:24449914)
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SwissProt ID
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Synonyms
TNPO 3; Imp12; Importin 12; IPO12; MTR10A; TNPO3; Transportin 3; Transportin SR; TRN-SR2; TRNSR
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Research Field
Signal Transduction
Documentation
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