TNPO3 - transportin 3 Gene

Also Known as IPO12; TRNSR; LGMD1F; LGMDD2; MTR10A; TRN-SR; TRN-SR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23534

About TNPO3

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,954,185-129,056,193 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 16.7), thyroid (RPKM 13.7) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 Infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]

TNPO3 Products (10)

mRNA	Protein	Name
NM_001191028.3	NP_001177957.2	transportin-3 isoform 2
NM_001382216.1	NP_001369145.1	transportin-3 isoform 3
NM_001382217.1	NP_001369146.1	transportin-3 isoform 4
NM_001382218.1	NP_001369147.1	transportin-3 isoform 5
NM_001382219.1	NP_001369148.1	transportin-3 isoform 6
NM_001382220.1	NP_001369149.1	transportin-3 isoform 7
NM_001382221.1	NP_001369150.1	transportin-3 isoform 8
NM_001382222.1	NP_001369151.1	transportin-3 isoform 9
NM_001382223.1	NP_001369152.1	transportin-3 isoform 10
NM_012470.4	NP_036602.1	transportin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22872640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12628928	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	23878195	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	12628928	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in annulate lamellae	IDA IDA: Inferred from direct assay	31192305	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	31192305	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNPO3 Protein Structure

Xpo1

0
200
400
600
800
923 a.a.

Protein Preferred Names	Protein Names
transportin-3	imp12

TNPO3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNPO3	Q9Y5L0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	TNPO3	Homo sapiens	Q9Y5L0	Solution Sedimentation	22872640
Intra	TNPO3	Q9Y5L0	TNPO3	Homo sapiens	Q9Y5L0	GMS	22872640
Intra	TNPO3	Q9Y5L0	CLK3	Homo sapiens	P49761	Anti Tag CoIP	35271311
Intra	TNPO3	Q9Y5L0	TNPO3	Homo sapiens	Q9Y5L0	SAXS	22872640
Intra	TNPO3	Q9Y5L0	CLPP	Homo sapiens	Q16740	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	CLPP	Homo sapiens	Q16740	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	CAMK2D	Homo sapiens	Q13557-8	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	CAMK2D	Homo sapiens	Q13557-8	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	CAMK2G	Homo sapiens	Q13555-5	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	CAMK2G	Homo sapiens	Q13555-5	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	SSX2	Homo sapiens	Q16385-2	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	SSX2	Homo sapiens	Q16385-2	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	PPP1R1C	Homo sapiens	Q8WVI7	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	PPP1R1C	Homo sapiens	Q8WVI7	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	ECI2	Homo sapiens	O75521	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	ECI2	Homo sapiens	O75521	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	BLMH	Homo sapiens	Q13867	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	BLMH	Homo sapiens	Q13867	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	NME1	Homo sapiens	P15531	Y2H Array	32296183
Intra	TNPO3	Q9Y5L0	NME1	Homo sapiens	P15531	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	GCH1	Homo sapiens	P30793	Y2H Prey Pooling	32296183
Intra	TNPO3	Q9Y5L0	GCH1	Homo sapiens	P30793	Y2H Array	32296183
Cross	TNPO3	Q9Y5L0	P04585-PRO_0000042447	Human immunodeficiency virus	P04585-PRO_0000042447	GMS	22872640
Cross	TNPO3	Q9Y5L0	P04585-PRO_0000042447	Human immunodeficiency virus	P04585-PRO_0000042447	Pull Down	22872640

Cross: Cross-species interaction Intra: Intraspecies interaction

TNPO3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82241	TNPO3 Antibody (YA1986)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2	Muscular Dystrophy, Limb-Girdle, Type 1f Lgmd1f Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1f LGMDD2 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 2 Muscular Dystrophy Limb-Girdle Type 1f Tnp03-Related Limb-Girdle Muscular Dystrophy D2 Lgmd Type 1f Limb-Girdle Muscular Dystrophy Type 1f Limb-Girdle Muscular Dystrophy 1f Dystrophy, Muscular, Limb-Girdle, Type 1f
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Autosomal Dominant Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Dominant
Muscular Dystrophy, Limb-Girdle, Type 1h	Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1h LGMD1H Muscular Dystrophy Limb-Girdle Type 1h Dystrophy, Muscular, Limb-Girdle, Type 1h
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 3	Lgmd1g Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1g LGMDD3 Muscular Dystrophy, Limb-Girdle, Type 1g Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 3 Limb-Girdle Muscular Dystrophy, Type 1g Muscular Dystrophy Limb-Girdle Type 1g Hnrnpdl-Related Limb-Girdle Muscular Dystrophy D3 Hnrnpdl-Related Lgmd D3 Lgmd Type 1g Limb-Girdle Muscular Dystrophy Type 1g Limb-Girdle Muscular Dystrophy 1g Dystrophy, Muscular, Limb-Girdle, Type 1g
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2	Lgmd2b Muscular Dystrophy, Limb-Girdle, Type 2b Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e Beta-Sarcoglycanopathy Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2y Muscular Dystrophy, Limb-Girdle, Type 3 Lgmd3 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2s LGMDR2 Muscular Dystrophy, Limb-Girdle, Type 2s Limb-Girdle Muscular Dystrophy Type 2b Lgmd2e Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency Muscular Dystrophy, Limb-Girdle, Type 2e Lgmd2s Autosomal Recessive Muscular Dystrophy Due To Lap1b Deficiency Autosomal Recessive Muscular Dystrophy Due To Torsin-1a-Interacting Protein 1 Deficiency Lgmd2y Muscular Dystrophy With Progressive Weakness, Distal Contractures And Rigid Spine Muscular Dystrophy, Limb-Girdle, Type 2y Dysferlin-Related Limb-Girdle Muscular Dystrophy R2 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b Dysferlin-Related Lgmd R2 Lgmd Due To Dysferlin Deficiency Lgmd Type 2b Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency Limb-Girdle Muscular Dystrophy 2b Limb-Girdle Muscular Dystrophy, Type 2b Dystrophy, Muscular, Limb-Girdle, Autosomal Recessive, Type 2 Dystrophy, Muscular, Limb-Girdle, Type 2b Limb-Girdle Muscular Dystrophy, Type 2e
Myopathy, Myofibrillar, 6	Myofibrillar Myopathy 6 MFM6 Myopathy, Myofibrillar, Bag3-Related Bag3-Related Myofibrillar Myopathy Muscular Dystrophy, Selcen Type Mfm Bag3-Related Muscular Dystrophy Selcen Type Myopathy Myofibrillar Bag3-Related
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2w	Lgmd2w Muscular Dystrophy, Limb-Girdle, Type 2w
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1	Muscular Dystrophy, Limb-Girdle, Type 1e Lgmd1d Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d LGMDD1 Lgmd1e Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1 Limb-Girdle Muscular Dystrophy Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly Lgmd1d, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e Muscular Dystrophy Limb-Girdle Type 1d Muscular Dystrophy Limb-Girdle Type 1e Dnajb6-Related Limb-Girdle Muscular Dystrophy D1 Dnajb6-Related Lgmd D1 Lgmd Type 1d Limb-Girdle Muscular Dystrophy 1e Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1 Dystrophy, Muscular, Limb-Girdle, Type 1e
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2q	Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Plectin Deficiency Lgmd2q Muscular Dystrophy, Limb-Girdle, Type 2q
Muscular Dystrophy-Dystroglycanopathy , Type C, 7	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2u Lgmd2u MDDGC7 Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 20 Lgmdr20 Muscular Dystrophy, Limb-Girdle, Type 2u Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Ispd Deficiency Muscular Dystrophy Limb-Girdle Type 2u Muscular Dystrophy-Dystroglycanopathy Type C7 Ispd-Related Limb-Girdle Muscular Dystrophy R20 Ispd-Related Lgmd R20 Lgmd Type 2u Limb-Girdle Muscular Dystrophy Type 2u Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C7 Dystrophy, Muscular, Dystroglycanopathy, Type C7
Myopathy	Muscular Diseases Myopathies
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14861	TNPO3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TNPO3	VGNC	VGNC:66432
Macaca mulatta	TNPO3	VGNC	VGNC:79063
Canis familiaris	TNPO3	VGNC	VGNC:47696
Rattus norvegicus	TNPO3	RGD	RGD:1308938
Mus musculus	TNPO3	MGD	MGI:1196412
Bos taurus	TNPO3	VGNC	VGNC:36201
Others	TNPO3	NCBI