PPP1R1C - protein phosphatase 1 regulatory inhibitor subunit 1C Gene

Also Known as IPP5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151242

About PPP1R1C

Cytogenetic location: 2q31.3-q32.1 Genomic coordinates (GRCh38): 2:181,954,480-182,131,385 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in heart (RPKM 4.6), testis (RPKM 4.4) and 5 other tissues.

Summary

Protein phosphatase-1 (PP1) is a major serine/threonine Phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

PPP1R1C Products (3)

mRNA Protein Name
NM_001080545.3 NP_001074014.1 protein phosphatase 1 regulatory subunit 1C isoform 2
NM_001261424.2 NP_001248353.1 protein phosphatase 1 regulatory subunit 1C isoform 1
NM_001261425.2 NP_001248354.1 protein phosphatase 1 regulatory subunit 1C isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R1C Protein Structure

DARPP-32

DARPP-32: Protein phosphatase inhibitor 1/DARPP-32 (1 - 105)

  • 0
  • 100
  • 109 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 1C

  • PP1 inhibitor protein 5

PPP1R1C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PPP1R1C Q8WVI7 TNPO3 Homo sapiens Q9Y5L0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Conduct Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10994 PPP1R1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP1R1C VGNC VGNC:33235
Canis familiaris PPP1R1C VGNC VGNC:44888
Felis catus PPP1R1C VGNC VGNC:80317
Macaca mulatta PPP1R1C VGNC VGNC:76256
Mus musculus PPP1R1C MGD MGI:1923185
Rattus norvegicus PPP1R1C RGD RGD:1562095
Others PPP1R1C NCBI