2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. REV-ERB
  4. SR10067

SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders.

For research use only. We do not sell to patients.

SR10067 Chemical Structure

SR10067 Chemical Structure

CAS No. : 1380548-02-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 308 In-stock
Solution
10 mM * 1 mL in DMSO USD 308 In-stock
Solid
5 mg USD 280 In-stock
10 mg USD 450 In-stock
25 mg USD 910 In-stock
50 mg USD 1450 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

SR10067 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders[1][2].

IC50 & Target

IC50: 160 nM (Rev-Erbβ); 170 nM (Rev-Erbα)[1]
In Vitro

SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR10067 Related Antibodies
In Vivo

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 30 mg/kg
Administration: i.p.
Result: Remained above the IC50 of the receptor in plasma and brain concentrations.
Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity.
Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
Molecular Weight

465.58

Formula

C31H31NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(OC1=CC=C(OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C=C1)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1479 mL 10.7393 mL 21.4786 mL
5 mM 0.4296 mL 2.1479 mL 4.2957 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (253 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1479 mL 10.7393 mL 21.4786 mL 53.6965 mL
5 mM 0.4296 mL 2.1479 mL 4.2957 mL 10.7393 mL
10 mM 0.2148 mL 1.0739 mL 2.1479 mL 5.3696 mL
15 mM 0.1432 mL 0.7160 mL 1.4319 mL 3.5798 mL
20 mM 0.1074 mL 0.5370 mL 1.0739 mL 2.6848 mL
25 mM 0.0859 mL 0.4296 mL 0.8591 mL 2.1479 mL
30 mM 0.0716 mL 0.3580 mL 0.7160 mL 1.7899 mL
40 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3424 mL
50 mM 0.0430 mL 0.2148 mL 0.4296 mL 1.0739 mL
60 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8949 mL
80 mM 0.0268 mL 0.1342 mL 0.2685 mL 0.6712 mL
100 mM 0.0215 mL 0.1074 mL 0.2148 mL 0.5370 mL
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SR10067 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR100671380548-02-6SR 10067SR-10067REV-ERBbrain penetrantRev-ErbβRev-Erbαmetabolic diseasesneuropsychiatric disordersInhibitorinhibitorinhibit

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