1. Metabolic Enzyme/Protease
  2. ROR
  3. SR2211

SR2211 

Cat. No.: HY-16998 Purity: >98.0%
Handling Instructions

SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

For research use only. We do not sell to patients.

SR2211 Chemical Structure

SR2211 Chemical Structure

CAS No. : 1359164-11-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 151 In-stock
Estimated Time of Arrival: December 31
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

IC50 & Target

IC50: ~320 nM (RORγ), Ki: 105 nM (RORγ)[1][2].

In Vitro

The treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

527.48

Formula

C₂₆H₂₄F₇N₃O

CAS No.

1359164-11-6

SMILES

FC1=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2)C=CC(C(C(F)(F)F)(O)C(F)(F)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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SR2211
Cat. No.:
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SR2211

Cat. No.: HY-16998