1. Metabolic Enzyme/Protease
  2. ROR

SR2211 

Cat. No.: HY-16998 Purity: >98.0%
Handling Instructions

SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

For research use only. We do not sell to patients.

SR2211 Chemical Structure

SR2211 Chemical Structure

CAS No. : 1359164-11-6

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10 mg USD 140 Get quote
25 mg USD 290 Get quote
50 mg USD 490 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

IC50 & Target

IC50: ~320 nM (RORγ), Ki: 105 nM (RORγ)[1][2].

In Vitro

The treatment of EL4 with SR2211 represses the Il17 gene expression to a greater extent as compared to digoxin. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211 and digoxin, as has been previously reported. Treatment of EL-4 cells with SR2211 as well as a control digoxin results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8958 mL 9.4790 mL 18.9581 mL
5 mM 0.3792 mL 1.8958 mL 3.7916 mL
10 mM 0.1896 mL 0.9479 mL 1.8958 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

527.48

Formula

C₂₆H₂₄F₇N₃O

CAS No.

1359164-11-6

SMILES

FC1=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2)C=CC(C(C(F)(F)F)(O)C(F)(F)F)=C1

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
SR2211
Cat. No.:
HY-16998
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SR2211

Cat. No.: HY-16998