2. Cell Cycle/DNA Damage
    Vitamin D Related/Nuclear Receptor
  3. PPAR
  4. SR1664

SR1664 

Cat. No.: HY-12483 Purity: ≥98.0%
COA Handling Instructions

SR1664 is a PPARγ antagonist. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50=80 nM; Ki= 28.67 nM).

For research use only. We do not sell to patients.

SR1664 Chemical Structure

SR1664 Chemical Structure

CAS No. : 1338259-05-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 180 In-stock
25 mg USD 390 In-stock
50 mg USD 690 In-stock
100 mg USD 1150 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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  • Customer Review

Description

SR1664 is a PPARγ antagonist. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50=80 nM; Ki= 28.67 nM)[1][2].

IC50 & Target

PPAR-γ

80 nM (IC50)

In Vitro

SR1664 (1uM; HEK293T cells) pharmacological effect on PPARγ activity is altered by mutagenesis of F282 to alanine (F282A)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

547.60

Appearance

Solid

Formula

C33H29N3O5
CAS No.
SMILES

O=C(C1=CC=CC=C1C2=CC=C(CN3C(C)=C(C)C4=C3C=CC(C(N[[email protected]](C5=CC=C([N+]([O-])=O)C=C5)C)=O)=C4)C=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8262 mL 9.1308 mL 18.2615 mL
5 mM 0.3652 mL 1.8262 mL 3.6523 mL
10 mM 0.1826 mL 0.9131 mL 1.8262 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SR16641338259-05-4SR 1664SR-1664PPARPeroxisome proliferator-activated receptorsHEK293TF282dependentclashstereospecificityphosphorylationS273Inhibitorinhibitorinhibit

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