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  4. SR31527 chloride

SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.

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SR31527 chloride Chemical Structure

SR31527 chloride Chemical Structure

CAS No. : 311814-78-5

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SR31527 chloride Related Antibodies

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Description

SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation[1].

IC50 & Target

IC50: 6.6 µM (KIFC1)[1]
In Vitro

SR31527 chloride binds to KIFC1 with a Kd value of 25.4 nM[1].
SR31527 chloride (50 µM; 24 h) induces multiple spindle formation in MDA-MB-231, BT549 and MDA-MB-435s cells[1].
SR31527 chloride (0-100 µM; 96 h, 10-12 days) decreases the cell viability and colony formation of breast cancer cells and is less cytotoxic to LL47 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR31527 chloride Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231, BT549, MDA-MB-435s cells
Concentration: 0-100 µM
Incubation Time: 96 h
Result: Decreased cell viability with IC50s of 29, 33, 20 µM for MDA-MB-231, BT549, MDA-MB-435s cells, respectively.
Molecular Weight

319.81

Formula

C15H14ClN3OS
CAS No.
SMILES

COC1=CC=C(C=C1)C2=[N+](SC(N)=N2)C3=CC=CC=C3.[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SR31527 chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR31527311814-78-5SR 31527SR-31527KinesinantiproliferativeMDA-MB-231BT549MDA-MB-435s cellsLL47 cellsanticancerInhibitorinhibitorinhibit

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SR31527 chloride
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HY-118961
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