BLT-3 

BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease^[1].

BLT-3 inhibits SR-BI-mediated DiI uptake from DiI-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 0.51 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 2.3 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in Y1-BS1 cells, with an IC₅₀ of 1.7 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]cholesterol efflux to HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 17.2 μM^[1].
BLT-3 enhances the binding of ¹²⁵I-HDL to SR-BI in ldlA[mSR-BI] cells by increasing binding affinity (decreasing K_d and Koff) without altering Bmax, with an IC₅₀ of 46.5 μM for its binding-enhancing effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

271.32

C₁₉H₁₃NO

109940-24-1

N=1OC(C=2C=CC=CC2)=C3C=CC=C3C1C=4C=CC=CC4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002;99(24):15422-15427.  [Content Brief]