1. Apoptosis
    Protein Tyrosine Kinase/RTK
  2. Apoptosis
    ROS
    Bcl-2 Family
    Caspase
  3. Anticancer agent 56

Anticancer agent 56 

Cat. No.: HY-146444
Handling Instructions

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9.

For research use only. We do not sell to patients.

Anticancer agent 56 Chemical Structure

Anticancer agent 56 Chemical Structure

CAS No. : 2241915-59-1

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Description

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9[1].

IC50 & Target

IC50: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3[1]

Molecular Weight

383.83

Formula

C20H18ClN3O3

CAS No.
SMILES

COC1=C(C=C(C=C1)/C=C/C(C2=C(N(N=N2)C3=CC=C(C=C3)Cl)C)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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