MASTL/Aurora A-IN-1
Based on 1 Customer Validation
MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 321945-24-8
- Formula: C18H18N2OS
- Molecular Weight:310.41
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Aurora Kinase Isoforms
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Biological Activity
Chemical Information
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CAS No. 321945-24-8
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Appearance Solid
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Molecular Weight 310.41
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Formula C18H18N2OS
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Color White to off-white
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SMILES
O=C(NC1=C(C#N)C(CCCC2)=C2S1)CCC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 116.67 mg/mL (375.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2215 mL | 16.1077 mL | 32.2155 mL | 80.5386 mL |
| 5 mM | 0.6443 mL | 3.2215 mL | 6.4431 mL | 16.1077 mL | |
| 10 mM | 0.3222 mL | 1.6108 mL | 3.2215 mL | 8.0539 mL | |
| 15 mM | 0.2148 mL | 1.0738 mL | 2.1477 mL | 5.3692 mL | |
| 20 mM | 0.1611 mL | 0.8054 mL | 1.6108 mL | 4.0269 mL | |
| 25 mM | 0.1289 mL | 0.6443 mL | 1.2886 mL | 3.2215 mL | |
| 30 mM | 0.1074 mL | 0.5369 mL | 1.0738 mL | 2.6846 mL | |
| 40 mM | 0.0805 mL | 0.4027 mL | 0.8054 mL | 2.0135 mL | |
| 50 mM | 0.0644 mL | 0.3222 mL | 0.6443 mL | 1.6108 mL | |
| 60 mM | 0.0537 mL | 0.2685 mL | 0.5369 mL | 1.3423 mL | |
| 80 mM | 0.0403 mL | 0.2013 mL | 0.4027 mL | 1.0067 mL | |
| 100 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8054 mL |
MASTL/Aurora A-IN-1 Related Classifications
HY-W231513 Related Classifications
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