SCARB1 Antibody (YA1160)(PBS only)

Cat. No.: HY-P81415A: Data Sheet User Guide for Antibodies
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SCARB1 Antibody (YA1160) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

SCARB1 Antibody (YA1160) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCARB1.

Host

Rabbit

분자량

Predicted band size: 61 kDa;

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q8WTV0

Gene ID

949 [NCBI]

Immunogen

Recombinant protein of human Scavenging Receptor SR-BI

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218); (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718); (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Membrane, caveola; Multi-pass membrane protein

Expression：
Tissue_specificity:Broad expression

Isoforms & Post-Translational Modification：Q8WTV0 has 5 isomers: Q8WTV0-1: 60878 Da (predicted); Q8WTV0-2: 56973 Da (predicted); Q8WTV0-3: 45103 Da (predicted); Q8WTV0-4: 53579 Da (predicted); Q8WTV0-5: 56170 Da (predicted).
N-glycosylated;The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds

Subunit：The C-terminal region binds to PDZK1

Research Field

Microbiology

Synonyms

CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; Scavenging Receptor SR-BI

각종 서류

User Guide for Antibodies (1077 KB)