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Cat. No.: HY-13300A

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SR-3677 dihydrochloride

Name: SR-3677 dihydrochloride
Brand: MedChemExpress
SKU: HY-13300A
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC₅₀ values of 56 nM and 3 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1781628-88-3
화학식: C₂₂H₂₆Cl₂N₄O₄
분자량:481.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SR-3677 dihydrochloride Chemical Structure

CAS No.: 1781628-88-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC₅₀ values of 56 nM and 3 nM^[1].

IC₅₀ & Target

ROCK-I

56 nM (IC₅₀)

ROCK-II

3 nM (IC₅₀)

All ROCK Isoforms :

Chemical Information

CAS No. 1781628-88-3
분자량 481.37
화학식 C₂₂H₂₆Cl₂N₄O₄
SMILES

[H]Cl.[H]Cl.CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Patent

US20180263995A1.

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

SR-3677 dihydrochloride

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (1)
순도&문서
References

상품명:
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SR-3677 dihydrochloride

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SAR407899

LX7101

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Belumosudil

Narciclasine

Thiazovivin

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Publications Citing Use of MedChemExpress (MCE) SR-3677 dihydrochloride

All ROCK Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

Help & FAQs

Bioz

SR-3677 dihydrochloride

Y-27632

Y-33075

GSK429286A

Netarsudil hydrochloride

Y-33075 dihydrochloride

SAR407899

LX7101

Y-27632 dihydrochloride

Belumosudil

Narciclasine

Thiazovivin

Y-27632 dihydrochloride (GMP)

Publications Citing Use of MedChemExpress (MCE) SR-3677 dihydrochloride

All ROCK Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

Help & FAQs

SR-3677 dihydrochloride Related Classifications

HY-13300A Related Classifications

Bioz