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Isoforms Recommended: Cathepsin L
Results for "

Cathepsin L

" in MedChemExpress (MCE) Product Catalog:

290

Inhibitors & Agonists

1

Screening Libraries

4

Fluorescent Dyes

9

Biochemical Assay Reagents

62

Peptides

1

Inhibitory Antibodies

14

Natural
Products

10

Recombinant Proteins

2

Isotope-Labeled Compounds

3

Antibodies

12

Click Chemistry

1

Oligonucleotides

2

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10042
    Odanacatib
    10+ Cited Publications

    MK-0822

    		 Cathepsin Metabolic Disease Cancer
    Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K.
    Odanacatib
  • HY-103351
    Cathepsin G Inhibitor I

    		Cathepsin Inflammation/Immunology
    Cathepsin G Inhibitor I (Compound 7) is a potent, selective, reversible, competitive, non-peptidic Cathepsin G inhibitor (IC50 = 53 nM; Ki = 63 nM). Cathepsin G Inhibitor I can be used in research related to immune disorders .
    Cathepsin G Inhibitor I
  • HY-114374
    RO5461111

    		Cathepsin Inflammation/Immunology
    RO5461111 a highly specific and orally active antagonist of Cathepsin S with IC50s of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. RO5461111 can effectively inhibit the activation of antigen-specific T cells and B cells. RO5461111 can improve pulmonary inflammation and lupus nephritis .
    RO5461111
  • HY-134434
    Z-Arg-Arg-AMC hydrochloride
    1 Publications Verification

    		 Cathepsin Fluorescent Dye Others
    Z-Arg-Arg-AMC hydrochloride is a highly selective fluorescent Cathepsin B substrate. Z-Arg-Arg-AMC hydrochloride can be hydrolyzed by Cathepsin B to produce a fluorescent product for enzyme activity detection .
    Z-Arg-Arg-AMC hydrochloride
  • HY-N2905
    Aurantiamide acetate
    3 Publications Verification

    Asperglaucide

    		 Cathepsin Inflammation/Immunology
    Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases .
    Aurantiamide acetate
  • HY-15100
    Balicatib
    2 Publications Verification

    AAE581

    		 Cathepsin Inflammation/Immunology
    Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC50 values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis .
    Balicatib
  • HY-P1759
    N-CBZ-Phe-Arg-AMC

    Z-FR-AMC

    		 Cathepsin Others
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
    N-CBZ-Phe-Arg-AMC
  • HY-115733
    Cathepsin L-IN-2
    1 Publications Verification

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-142021
    Z-Leu-Arg-AMC

    		Cathepsin Parasite Infection Inflammation/Immunology
    Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .
    Z-Leu-Arg-AMC
  • HY-103352
    L-006235

    L-235

    		 Cathepsin Metabolic Disease
    L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss .
    L-006235
  • HY-P1759B
    N-CBZ-Phe-Arg-AMC TFA

    Z-FR-AMC TFA

    		 Cathepsin Others
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
    N-CBZ-Phe-Arg-AMC TFA
  • HY-100231
    Cathepsin inhibitor 1
    1 Publications Verification

    		 Cathepsin Inflammation/Immunology
    Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin inhibitor 1 is promising for research of osteoarthritis .
    Cathepsin inhibitor 1
  • HY-137841
    L-Arginine-7-amido-4-methylcoumarin hydrochloride

    Arginine 4-methyl-7-coumarylamide hydrochloride

    		 Cathepsin Others
    L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .
    L-Arginine-7-amido-4-methylcoumarin hydrochloride
  • HY-101779
    DCG04

    		Glycosidase Others
    DCG04 is a multivalent ligand for the mannose-6-phosphate receptor. DCG-04 is an activity-based probe for cysteine cathepsins, and can be used for labelling numerous cysteine cathepsins in cell and tissue lysates .
    DCG04
  • HY-141867
    Z-FF-FMK

    Z-Phe-Phe-FMK

    		 Cathepsin MEK Caspase DNA/RNA Synthesis Apoptosis Cardiovascular Disease Neurological Disease
    Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .
    Z-FF-FMK
  • HY-146985
    Cathepsin X-IN-1
    1 Publications Verification

    		 Cathepsin Neurological Disease Cancer
    Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC50 of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .
    Cathepsin X-IN-1
  • HY-146584
    Cathepsin C-IN-5

    		Cathepsin Inflammation/Immunology
    Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .
    Cathepsin C-IN-5
  • HY-102087
    JPM-OEt
    3 Publications Verification

    		 Cathepsin Cancer
    JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity .
    JPM-OEt
  • HY-N4289
    3-Epiursolic Acid
    1 Publications Verification

    		 Cathepsin Cancer
    3-Epiursolic Acid is a triterpenoid that can be isolated from Eriobotrya japonica, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B .
    3-Epiursolic Acid
  • HY-15958
    VBY-825
    1 Publications Verification

    		 Cathepsin Inflammation/Immunology Cancer
    VBY-825 is an orally available novel reversible cathepsin inhibitor that has high inhibitory potency against cathepsin B, L, S and V, and possesses anti-tumor, anti-inflammatory and analgesic effects .
    VBY-825
  • HY-118762
    KGP94

    		Cathepsin Cancer
    KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM . KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines .
    KGP94
  • HY-118959
    S2160

    Bz-Phe-Val-Arg-pNA

    		 Cathepsin Others
    S2160 is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B .
    S2160
  • HY-P3012
    Cathepsin G

    		Cathepsin ERK p38 MAPK PKC Protease Activated Receptor (PAR) MMP Inflammation/Immunology
    Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .
    Cathepsin G
  • HY-P1759A
    N-CBZ-Phe-Arg-AMC hydrochloride

    Z-FR-AMC hydrochloride

    		 Cathepsin Others
    N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
    N-CBZ-Phe-Arg-AMC hydrochloride
  • HY-P4217
    Z-Gly-Pro-Arg-AMC hydrochloride
    1 Publications Verification

    		 Cathepsin Others
    Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
    Z-Gly-Pro-Arg-AMC hydrochloride
  • HY-E70226
    Cathepsin S, human

    CTSS

    		 Ser/Thr Protease Cardiovascular Disease Inflammation/Immunology Cancer
    Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease .
    Cathepsin S, human
  • HY-W790014
    Z-FG-NHO-BzOME

    		Cathepsin Infection
    Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .
    Z-FG-NHO-BzOME
  • HY-P4306
    Z-Phe-Phe-Diazomethylketone

    		Cathepsin Inflammation/Immunology
    Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L .
    Z-Phe-Phe-Diazomethylketone
  • HY-W796158
    Z-DEVD-CMK

    		Cathepsin Inflammation/Immunology
    Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro .
    Z-DEVD-CMK
  • HY-152204
    Cathepsin L/S-IN-1

    		Cathepsin Cancer
    Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells .
    Cathepsin L/S-IN-1
  • HY-137392
    Cathepsin L-IN-4

    1-Naphthalenesulfonyl-Ile-Trp-CHO

    		 Cathepsin Others
    Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC50 at nanomolar concentrations .
    Cathepsin L-IN-4
  • HY-P2498A
    Cathepsin D and E FRET Substrate acetate

    		Cathepsin Cancer
    Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
    Cathepsin D and E FRET Substrate acetate
  • HY-P3153
    Cathepsin K
    1 Publications Verification

    		 Cathepsin Metabolic Disease
    Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis .
    Cathepsin K
  • HY-P4340A
    Arg-Arg-AMC acetate

    		Cathepsin Others
    Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .
    Arg-Arg-AMC acetate
  • HY-P4515
    Z-Phe-Arg-pNA

    		Cathepsin Others
    Z-Phe-Arg-pNA is a substrate of Cathepsin L .
    Z-Phe-Arg-pNA
  • HY-170772
    Dual Cathepsin L/JAK-IN-1

    		p38 MAPK STAT Interleukin Related Cathepsin JAK Inflammation/Immunology
    Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI) .
    Dual Cathepsin L/JAK-IN-1
  • HY-P2750
    Cathepsin D
    1 Publications Verification

    CTSD

    		 Biochemical Assay Reagents Cardiovascular Disease Neurological Disease Cancer
    Cathepsin D (CTSD) is a lysosomal aspartic protease encoded by the CTSD gene. Cathepsin D regulates lysosomal protease activity. Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases. Cathepsin D is involved in breast cancer metastasis. Cathepsin D can be used in research on diseases such as breast cancer and stroke .
    Cathepsin D
  • HY-U00377
    Cathepsin Inhibitor 2

    		Cathepsin Inflammation/Immunology Cancer
    Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.
    Cathepsin Inhibitor 2
  • HY-147774
    Cathepsin K inhibitor 6

    		Cathepsin Others
    Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC50 of 17 nM. Cathepsin K inhibitor 6 also has inhibitory effects on other isoforms, with IC50s of 0.05 μM (Cat L) and 0.3 μM (Cat B), respectively .
    Cathepsin K inhibitor 6
  • HY-P990387
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)

    		Ser/Thr Protease Inflammation/Immunology
    The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) is a humanized antibody expressed in CHO cells, targeting CTSS/Cathepsin S. The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CTSS/Cathepsin S Antibody (Fsn0503h) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
  • HY-158307
    Z-Arg-Arg-βNA acetate

    		Cathepsin Others
    Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .
    Z-Arg-Arg-βNA acetate
  • HY-P5378A
    Ac-KQKLR-AMC TFA

    Cathepsin S substrate TFA

    		 Ser/Thr Protease Others
    Ac-KQKLR-AMC TFA is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). Ac-KQKLR-AMC TFA can be used to measure Cathepsin S activity) .
    Ac-KQKLR-AMC TFA
  • HY-P11326
    Ac-FR-AFC TFA

    		Cathepsin Fluorescent Dye Neurological Disease Cancer
    Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma .
    Ac-FR-AFC TFA
  • HY-169171
    Cathepsin L-IN-5

    		Cathepsin Infection
    Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research .
    Cathepsin L-IN-5
  • HY-163389
    Mpro/Cathepsin L-IN-1

    		SARS-CoV Cathepsin Infection
    Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M pro/hCatL inhibitor, with Kis of 5.54 μM and 0.701 μM respectively .
    Mpro/Cathepsin L-IN-1
  • HY-50887
    L-873724

    		Cathepsin Metabolic Disease
    L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively . L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption .
    L-873724
  • HY-P2498
    Cathepsin D and E FRET Substrate

    		Cathepsin Others
    Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
    Cathepsin D and E FRET Substrate
  • HY-177315
    Cathepsin K-IN-8

    		Cathepsin Inflammation/Immunology Cancer
    Cathepsin K-IN-8 (cxample 6-60) is a cathepsin K inhibitor that can be used for the study of inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors .
    Cathepsin K-IN-8
  • HY-112583
    MIV-247

    		Cathepsin Neurological Disease
    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
    MIV-247
  • HY-P5378
    Ac-KQKLR-AMC

    Cathepsin S substrate

    		 Ser/Thr Protease Others
    Ac-KQKLR-AMC is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). Ac-KQKLR-AMC can be used to measure Cathepsin S activity) .
    Ac-KQKLR-AMC

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