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Art. -Nr.: HY-139111

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Oxocarbazate

Oxocarbazate is an inhibitor of human cathepsin L with the IC₅₀ values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC₅₀ = 273 nM) and Ebola virus (IC₅₀ = 193 nM) entry into 293T cells.

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CAS. Nr.: 1014405-03-8
Formel: C₂₈H₃₃N₅O₆
Molecular Weight:535.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Oxocarbazate Chemical Structure

CAS. Nr.: 1014405-03-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	193 μM Compound: 44; CID 23631927	Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay	[PMID: 33486200]
HEK-293T	IC₅₀	273 μM Compound: 44; CID 23631927	Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay	[PMID: 33486200]

Chemical Information

CAS. Nr. 1014405-03-8
Molecular Weight 535.59
Formel C₂₈H₃₃N₅O₆
SMILES

O=C(N1C2=CC=CC=C2CCC1)COC(NNC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=CC=CC=C34)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shah PP, et al. A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol. 2010;78(2):319-324. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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