Oxocarbazate
Oxocarbazate is an inhibitor of human cathepsin L with the IC50 values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into 293T cells.
For research use only. We do not sell to patients.
- CAS No.: 1014405-03-8
- Formula: C28H33N5O6
- Molecular Weight:535.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Cathepsin Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
193 μM
Compound: 44; CID 23631927
|
Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay
Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay
|
[PMID: 33486200] |
| HEK-293T | IC50 |
273 μM
Compound: 44; CID 23631927
|
Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay
Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay
|
[PMID: 33486200] |
Chemical Information
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CAS No. 1014405-03-8
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Molecular Weight 535.59
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Formula C28H33N5O6
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SMILES
O=C(N1C2=CC=CC=C2CCC1)COC(NNC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=CC=CC=C34)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)