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Cat. No.: HY-139111

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Oxocarbazate

Oxocarbazate is an inhibitor of human cathepsin L with the IC₅₀ values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC₅₀ = 273 nM) and Ebola virus (IC₅₀ = 193 nM) entry into 293T cells.

For research use only. We do not sell to patients.

CAS No.: 1014405-03-8
Formula: C₂₈H₃₃N₅O₆
Molecular Weight:535.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Oxocarbazate Chemical Structure

CAS No.: 1014405-03-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Cathepsin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	193 μM Compound: 44; CID 23631927	Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay Antiviral activity against Ebolavirus infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay	[PMID: 33486200]
HEK-293T	IC₅₀	273 μM Compound: 44; CID 23631927	Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay Antiviral activity against SARS-CoV infected in HEK293T cells assessed as reduction in viral replication incubated for 7 hrs by luciferase assay	[PMID: 33486200]

Chemical Information

CAS No. 1014405-03-8
Molecular Weight 535.59
Formula C₂₈H₃₃N₅O₆
SMILES

O=C(N1C2=CC=CC=C2CCC1)COC(NNC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=CC=CC=C34)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shah PP, et al. A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol. 2010;78(2):319-324. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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