Alloc-Val-Ala-pAB
Based on 1 Customer Validation
Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.02%
- CAS No.: 1343407-91-9
- 화학식: C19H27N3O5
- 분자량:377.43
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
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Help & FAQs
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HY-136136
Fmoc-Val-Ala-PAB-PNP
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HY-135975
MC-Val-Ala-PAB-PNP
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HY-126364
Mc-Val-Ala-PAB
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HY-130932
Boc-Val-Ala-PAB-PNP
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HY-126353
Fmoc-Val-Ala-PAB-OH
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HY-125933
Val-Ala-PAB
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HY-136547
Boc-Val-Ala-PAB
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HY-20336
Mc-Val-Cit-PABC-PNP
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-W106311
Fmoc-Val-Ala-OH
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HY-W591374
DBCO-PEG4-Val-Ala-PAB-PNP
Biological Activity
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1343407-91-9
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Appearance Solid
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분자량 377.43
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화학식 C19H27N3O5
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Color Off-white to gray
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SMILES
OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCC=C)=O)C(C)C)=O)C)=O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 10 mg/mL (26.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6495 mL | 13.2475 mL | 26.4950 mL | 66.2374 mL |
| 5 mM | 0.5299 mL | 2.6495 mL | 5.2990 mL | 13.2475 mL | |
| 10 mM | 0.2649 mL | 1.3247 mL | 2.6495 mL | 6.6237 mL | |
| 15 mM | 0.1766 mL | 0.8832 mL | 1.7663 mL | 4.4158 mL | |
| 20 mM | 0.1325 mL | 0.6624 mL | 1.3247 mL | 3.3119 mL | |
| 25 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6495 mL |
Alloc-Val-Ala-pAB Related Classifications
HY-W071967 Related Classifications
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