TB-9
TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC50s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1415033-91-8
- Formula: C55H76N8O12
- Molecular Weight:1041.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cathepsin Isoforms
More
Biological Activity
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Cathepsin D 0.0783 nM (IC50) |
Cathepsin E 0.724 nM (IC50) |
BACE1 54.2 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: TB-9
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
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[PMID: 35121401] |
| HepG2 | IC50 |
>10 μM
Compound: TB-9
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
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[PMID: 35121401] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: TB-9
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
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[PMID: 35121401] |
Chemical Information
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CAS No. 1415033-91-8
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Molecular Weight 1041.24
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Formula C55H76N8O12
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(OC)=O)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TB-9 Related Classifications
HY-164956 Related Classifications
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