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Cat. No.: HY-P4340A

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Arg-Arg-AMC acetate

Name: Arg-Arg-AMC acetate
Brand: MedChemExpress
SKU: HY-P4340A
Price: 50.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Arg-Arg-AMC acetate is a fluorescent dipeptidyl peptidase substrate. Arg-Arg-AMC acetate is hydrolyzed by dipeptidyl peptidase III as a reference substrate, releasing the fluorescent coumarin AMC upon cleavage, thereby enabling monitoring of dipeptidyl peptidase/protease activity in fluorescence assays.

For research use only. We do not sell to patients.

Purity : 99.55%
Formula: C₂₂H₃₃N₉O₄.xC₂H₄O₂
Molecular Weight:487.56 (free base)

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Arg-Arg-AMC acetate Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Dipeptidyl Peptidase Isoforms :

In Vitro

Protein/Amino Acid MetabolismOthers

Protein/Amino Acid Metabolism

Arg-Arg-AMC (0.5 mM; 20 min) acetate is hydrolyzed by DPP III (relative activity 100%) but not by DPP I, DPP II, or DPP IV (relative activity 0%) in assays with purified porcine skeletal muscle DPP^[1].

Others

Arg-Arg-AMC (0.25 mM; 10-120 min) acetate supports a higher dipeptidyl aminopeptidase III activity in synovial fluid sample group B (0.17 nmol/h per mg protein) than in synovial fluid sample group A (0.09 nmol/h per mg protein)^[2].
Arg-Arg-AMC (0.25 mM; 10-120 min) acetate supports a dipeptidyl aminopeptidase III activity of 0.4 nmol/h per mg protein in plasma sample group A and 0.03 nmol/h per mg protein in plasma sample group B^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 487.56 (free base)
Formula C₂₂H₃₃N₉O₄.xC₂H₄O₂
Color White to off-white
Sequence

Arg-Arg-{AMC}
Sequence Shortening

RR-{AMC}
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg
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g
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miguel Angel Sentandreu, et al. Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases, Food Chemistry, Volume 102, Issue 2, 2007, Pages 511-515, ISSN 0308-8146.

[2]. Mantle D, et al. Quantification of protease activities in synovial fluid from rheumatoid and osteoarthritis cases: comparison with antioxidant and free radical damage markers. Clinica chimica acta; international journal of clinical chemistry. 1999 Jun 15;284(1):45-58.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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