2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Cathepsin Beta-secretase
  4. TB-11

TB-11 is a Cathepsin D inhibitor, with IC50s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research.

For research use only. We do not sell to patients.

TB-11

TB-11 Chemical Structure

CAS No. : 1415033-93-0

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TB-11 Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

View All Beta-secretase Isoform Specific Products:

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BACE1 BACE2

  • Biological Activity

  • Purity & Documentation

  • References

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Description

TB-11 is a Cathepsin D inhibitor, with IC50s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research[1].

IC50 & Target[1]

Cathepsin D

0.126 nM (IC50)

Cathepsin E

1.92 nM (IC50)

BACE1

48.8 nM (IC50)

Molecular Weight

1007.22

Formula

C52H78N8O12
CAS No.
Appearance

Solid

Color

white

SMILES

CC(C)(C)OC(N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(OC)=O)=O)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9928 mL 4.9642 mL 9.9283 mL
5 mM 0.1986 mL 0.9928 mL 1.9857 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9928 mL 4.9642 mL 9.9283 mL 24.8208 mL
5 mM 0.1986 mL 0.9928 mL 1.9857 mL 4.9642 mL
10 mM 0.0993 mL 0.4964 mL 0.9928 mL 2.4821 mL
15 mM 0.0662 mL 0.3309 mL 0.6619 mL 1.6547 mL
20 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2410 mL
25 mM 0.0397 mL 0.1986 mL 0.3971 mL 0.9928 mL
30 mM 0.0331 mL 0.1655 mL 0.3309 mL 0.8274 mL
40 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6205 mL
50 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4964 mL
60 mM 0.0165 mL 0.0827 mL 0.1655 mL 0.4137 mL
80 mM 0.0124 mL 0.0621 mL 0.1241 mL 0.3103 mL
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TB-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TB-111415033-93-0TB11TB 11CathepsinBeta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

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