Phe-Lys(Trt)-PAB
Based on 1 Customer Validation
Phe-Lys(Trt)-PAB is a cathepsin B substrate, and a cleavable ADC linker. Phe-Lys(Trt)-PAB acts as a lysosomally cleavable substrate for cysteine protease cathepsin B, with cleavage enabling linked anticancer drug release via self-immolative spacer . Phe-Lys(Trt)-PAB can be used for synthesis of ADCs.
For research use only. We do not sell to patients.
- Purity: 96.24%
- CAS No.: 1116085-99-4
- Formula: C41H44N4O3
- Molecular Weight:640.81
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Protease Cleavable Linker |
Cleavable Linker |
Phe-Lys(Trt)-PAB linker within human serum albumin-conjugated prodrug HSA-16 is efficiently cleaved by cathepsin B at pH 5.0 and 37 °C, releasing free Doxorubicin (HY-15142) and Paclitaxel (HY-B0015) with near-complete cleavage observed after 20 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1116085-99-4
-
Appearance Solid
-
Molecular Weight 640.81
-
Formula C41H44N4O3
-
Color White to off-white
-
SMILES
OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (390.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5605 mL | 7.8026 mL | 15.6052 mL | 39.0131 mL |
| 5 mM | 0.3121 mL | 1.5605 mL | 3.1210 mL | 7.8026 mL | |
| 10 mM | 0.1561 mL | 0.7803 mL | 1.5605 mL | 3.9013 mL | |
| 15 mM | 0.1040 mL | 0.5202 mL | 1.0403 mL | 2.6009 mL | |
| 20 mM | 0.0780 mL | 0.3901 mL | 0.7803 mL | 1.9507 mL | |
| 25 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5605 mL | |
| 30 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3004 mL | |
| 40 mM | 0.0390 mL | 0.1951 mL | 0.3901 mL | 0.9753 mL | |
| 50 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL | |
| 60 mM | 0.0260 mL | 0.1300 mL | 0.2601 mL | 0.6502 mL | |
| 80 mM | 0.0195 mL | 0.0975 mL | 0.1951 mL | 0.4877 mL | |
| 100 mM | 0.0156 mL | 0.0780 mL | 0.1561 mL | 0.3901 mL |
Powered by Bioz