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Cat. No.: HY-155667

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Z-Nle-Lys-Arg-AMC

Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range.

For research use only. We do not sell to patients.

CAS No.: 1135364-14-5
Formula: C₃₆H₅₀N₈O₇
Molecular Weight:706.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Z-Nle-Lys-Arg-AMC Chemical Structure

CAS No.: 1135364-14-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range^[1].

All Cathepsin Isoforms :

Chemical Information

CAS No. 1135364-14-5
Molecular Weight 706.83
Formula C₃₆H₅₀N₈O₇
SMILES

CCCC[C@@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC1=CC(O2)=C(C=C1)C(C)=CC2=O)=O)=O)CCCCN)=O)NC(OCC3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoon MC, et al. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 Aug 1;62(15):2289-2300. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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Z-Nle-Lys-Arg-AMC

All Cathepsin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Z-Nle-Lys-Arg-AMC Related Classifications

HY-155667 Related Classifications