1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. VBY-825

VBY-825 

Cat. No.: HY-15958
Handling Instructions

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.

For research use only. We do not sell to patients.

VBY-825 Chemical Structure

VBY-825 Chemical Structure

CAS No. : 1310340-58-9

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5 mg USD 850 Ask For Quote & Lead Time
10 mg USD 1450 Ask For Quote & Lead Time

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Description

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V. IC50 value: Target: 130/250/250/330/2.3/4.7 nM(Ki for cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F) [1] VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

Molecular Weight

535.55

Formula

C₂₃H₂₉F₄N₃O₅S

CAS No.

1310340-58-9

SMILES

CC[[email protected]](NC([[email protected]@H](N[[email protected]@H](C1=CC=C(F)C=C1)C(F)(F)F)CS(=O)(CC2CC2)=O)=O)C(C(NC3CC3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (233.40 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8672 mL 9.3362 mL 18.6724 mL
5 mM 0.3734 mL 1.8672 mL 3.7345 mL
10 mM 0.1867 mL 0.9336 mL 1.8672 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.88 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VBY-825VBY825VBY 825CathepsinInhibitorinhibitorinhibit

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Product Name:
VBY-825
Cat. No.:
HY-15958
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