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Cat. No.: HY-181927

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SARS-CoV-2 PLpro-IN-7

SARS-CoV-2 PLpro-IN-7 (Compound 18) is a selective SARS-CoV-2 PLpro inhibitor with an IC₅₀ of 13.3 μM. SARS-CoV-2 PLpro-IN-7 exerts antiviral activity against SARS-CoV-2 (with an EC₅₀ of 11 μM for SARS-CoV-2 in Huh7.5 cells). SARS-CoV-2 PLpro-IN-7 is applicable to research related to COVID-19.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₀F₃N₃O₄
Molecular Weight:541.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2 PLpro-IN-7 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

SARS-CoV-2 PLpro

13.3 μM (IC₅₀)

In Vitro

SARS-CoV-2 PLpro-IN-7 (0.2-200 μM; 30 min) inhibits purified SARS-CoV-2 PLpro with an IC₅₀ of 13.3 ± 9 μM; after a 30-min pre-incubation, the inhibition rate reaches 80% at a concentration of 50 μM^[1].
SARS-CoV-2 PLpro-IN-7 (0.156-20 μM; 48 h) inhibits SARS-CoV-2 replication in Huh7.5 cells, with an EC₅₀ of 11 ± 2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 541.56
Formula C₂₉H₃₀F₃N₃O₄
SMILES

CCOC(/C=C/CNC(CCNC(C=CC(C(F)(F)F)=C1)=C1C(N[C@H](C)C2=CC=CC3=C2C=CC=C3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang HY, et al. Integration of computational and experimental techniques for the discovery of PL^pro covalent inhibitors. When large virtual screening and rational design meet. Eur J Med Chem. 2026;308:118698. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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