BI-1124

Cat. No.: HY-171925: Data Sheet Handling Instructions
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BI-1124 is a cathepsin S inhibitor that exhibits simulated sufficient ocular pharmacokinetic-pharmacodynamic coverage in rabbit models via topical ocular administration. BI-1124 can be used for the research of age-related dry eye disease.

For research use only. We do not sell to patients.

BI-1124 Chemical Structure

CAS No. : 752237-69-7

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•Related Small Molecules:

•Related Proteins:

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

cathepsin S

In Vitro

BI-1124 (0.075 mg/mL, 0.0075% w/v) exhibits high corneal permeability, sufficient solubility, and a suitable partition coefficient at pH 7.4 in in silico ADMET and ocular pharmacokinetic analyses. After simulated topical administration, its concentrations in rabbit cornea and conjunctiva can remain sustained above the in vitro IC₅₀ (7 nM) and IC₉₀ (70 nM) levels, which supports its potential to be repurposed for age-related dry eye disease through the inhibition of cathepsin S^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.59

Formula

C₂₂H₃₉N₅O₃

CAS No.

752237-69-7

SMILES

N(C([C@@H](NC(=O)N1CCOCC1)CCC(C)(C)C)=O)C2(C#N)CCN(CCC)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Baltazar B, et al. In silico simulation models for preclinical pharmacokinetic profiling in drug repositioning of a cathepsin S inhibitor for age-related dry eye. Investigative Ophthalmology & Visual Science. 2024 Jun 17;65(7):6124-.

BI-1124 Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-1124752237-69-7BI1124BI 1124Cathepsinage-related dry eyerabbit corneacathepsin Scorneal permeabilityconjunctivarabbit modelstopical ophthalmic deliveryInhibitorinhibitorinhibit

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