2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Val-Cit-PAB-Exatecan

Val-Cit-PAB-Exatecan  (Synonyms: Val-Cit-PAB-DX8951)

Cat. No.: HY-153031 Purity: 99.21%
COA Handling Instructions

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Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker.

For research use only. We do not sell to patients.

Val-Cit-PAB-Exatecan Chemical Structure

Val-Cit-PAB-Exatecan Chemical Structure

CAS No. : 2227350-99-2

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Based on 1 publication(s) in Google Scholar

Val-Cit-PAB-Exatecan Related Antibodies

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Description

Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker[1].

Molecular Weight

840.90

Formula

C43H49FN8O9
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.21%

COA (261 KB) HNMR (374 KB) LCMS (131 KB)

Handling Instructions (2659 KB)
References
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Val-Cit-PAB-Exatecan Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Cit-PAB-Exatecan2227350-99-2Val-Cit-PAB-DX8951Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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