2. Anti-infection Metabolic Enzyme/Protease
  3. Cathepsin SARS-CoV
  4. Olgotrelvir sodium

Olgotrelvir sodium  (Synonyms: STI-1558 sodium)

Cat. No.: HY-156655A Purity: ≥95.0%
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Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells.

For research use only. We do not sell to patients.

Olgotrelvir sodium Chemical Structure

Olgotrelvir sodium Chemical Structure

CAS No. : 2763596-72-9

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1200 In-stock
10 mg USD 1980 In-stock
25 mg USD 3950 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells[1].

Molecular Weight

516.54

Formula

C22H29N4NaO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@H](CC(C)C)NC(C2=CC3=CC=CC=C3N2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (96.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9360 mL 9.6798 mL 19.3596 mL
5 mM 0.3872 mL 1.9360 mL 3.8719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9360 mL 9.6798 mL 19.3596 mL 48.3990 mL
5 mM 0.3872 mL 1.9360 mL 3.8719 mL 9.6798 mL
10 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8399 mL
15 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2266 mL
20 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4199 mL
25 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9360 mL
30 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6133 mL
40 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2100 mL
50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
60 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8066 mL
80 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Olgotrelvir sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olgotrelvir2763596-72-9STI-1558STI1558STI 1558CathepsinSARS-CoVSARS coronaviruscoronavirus main proteaseMproSARS-CoV-2Inhibitorinhibitorinhibit

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