Tetromycin A
Tetromycin A is a tetronic acid-based antibiotic. It reportedly has pronounced activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Related tetromycin derivatives have been found to have anti-trypanosomal activity and inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range.
For research use only. We do not sell to patients.
- CAS No.: 180027-83-2
- Formula: C36H48O6
- Molecular Weight:576.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H460 | IC50 |
>30 μM
Compound: 13
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Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay
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[PMID: 35640100] |
| SW-620 | IC50 |
>30 μM
Compound: 13
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Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay
Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay
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[PMID: 35640100] |
Chemical Information
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CAS No. 180027-83-2
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Molecular Weight 576.76
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Formula C36H48O6
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SMILES
CC1=C[C@]2([C@@]([H])([C@H](CC[C@@H]2OC(C)=O)C)[C@@](C)([C@@]1(/C(C)=C/CC/C(C)=C/[C@]3([C@]4(C[C@H](C(C)=C3)C)OC5=O)C)[H])C(C5=C4O)=O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetromycin A Related Classifications
HY-122523 Related Classifications
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