2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Cathepsin Interleukin Related
  4. Cathepsin L-IN-6

Cathepsin L-IN-6 (Compound 6a) is a selective cathepsin L inhibitor with an IC50 of 0.021 μM. Cathepsin L-IN-6 suppresses cathepsin L activity by directly binding to cathepsin L. Cathepsin L-IN-6 inhibits IL-6 and IL-8. Cathepsin L-IN-6 shows a high anti-inflammatory activity. Cathepsin L-IN-6 can be used in the research of acute lung injury.

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Cathepsin L-IN-6

Cathepsin L-IN-6 Chemical Structure

CAS No. : 3077842-39-5

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Cathepsin L-IN-6 Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

Cathepsin L-IN-6 (Compound 6a) is a selective cathepsin L inhibitor with an IC50 of 0.021 μM. Cathepsin L-IN-6 suppresses cathepsin L activity by directly binding to cathepsin L. Cathepsin L-IN-6 inhibits IL-6 and IL-8. Cathepsin L-IN-6 shows a high anti-inflammatory activity. Cathepsin L-IN-6 can be used in the research of acute lung injury[1].

IC50 & Target[1]

cathepsin L

0.021 μM (IC50)

Cathepsin B

7.41 μM (IC50)

Cathepsin C

27.92 μM (IC50)

cathepsin S

5.87 μM (IC50)

CTSH

0.627 μM (IC50)

IL-6

 

IL-8

 

Molecular Weight

418.46

Formula

C24H23FN4O2
CAS No.
SMILES

O=C(C1=CC=C(C=C1)F)NCCCCCN2C=CC3=C(N=CN=C32)OC4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cathepsin L-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin L-IN-63077842-39-5CathepsinInterleukin RelatedILacute lung injuryanti-inflammatoryInhibitorinhibitorinhibit

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