1. Metabolic Enzyme/Protease
  2. Proteasome Cathepsin
  3. ALLM

ALLM  (Synonyms: Calpain inhibitor II)

Cat. No.: HY-118355 Purity: ≥98.0%
COA Handling Instructions

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

For research use only. We do not sell to patients.

ALLM Chemical Structure

ALLM Chemical Structure

CAS No. : 110115-07-6

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 185 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

In Vivo

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2].
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2]
Dosage: 0.05, 0.5, and 2.5 mg/kg
Administration: Intraperitoneally; every 24 h for 1 week
Result: Showed significantly better motor function.
Molecular Weight

401.56

Formula

C19H35N3O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CSCC[C@@H](C=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (49.81 mM)

Ethanol : ≥ 20 mg/mL (49.81 mM)

DMSO : ≥ 20 mg/mL (49.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4903 mL 12.4514 mL 24.9029 mL
5 mM 0.4981 mL 2.4903 mL 4.9806 mL
10 mM 0.2490 mL 1.2451 mL 2.4903 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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ALLM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ALLM
Cat. No.:
HY-118355
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