1. Metabolic Enzyme/Protease
  2. Proteasome
    Cathepsin
  3. ALLM

ALLM  (Synonyms: Calpain inhibitor II)

Cat. No.: HY-118355
Handling Instructions

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

For research use only. We do not sell to patients.

ALLM Chemical Structure

ALLM Chemical Structure

CAS No. : 110115-07-6

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Description

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

In Vivo

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2].
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2]
Dosage: 0.05, 0.5, and 2.5 mg/kg
Administration: Intraperitoneally; every 24 h for 1 week
Result: Showed significantly better motor function.
Molecular Weight

401.56

Formula

C19H35N3O4S

CAS No.
SMILES

CSCC[[email protected]@H](C=O)NC([[email protected]](CC(C)C)NC([[email protected]](CC(C)C)NC(C)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ALLM
Cat. No.:
HY-118355
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