1. Metabolic Enzyme/Protease
  2. Proteasome
    Cathepsin
  3. ALLM

ALLM (Synonyms: Calpain inhibitor II)

Cat. No.: HY-118355
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ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

For research use only. We do not sell to patients.

ALLM Chemical Structure

ALLM Chemical Structure

CAS No. : 110115-07-6

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Description

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

In Vivo

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2].
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2].

Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2]
Dosage: 0.05, 0.5, and 2.5 mg/kg
Administration: Intraperitoneally; every 24 h for 1 week
Result: Showed significantly better motor function.
Molecular Weight

401.56

Formula

C₁₉H₃₅N₃O₄S

CAS No.

110115-07-6

SMILES

CSCC[[email protected]@H](C=O)NC([[email protected]](CC(C)C)NC([[email protected]](CC(C)C)NC(C)=O)=O)=O

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Keywords:

ALLMCalpain inhibitor IIProteasomeCathepsinneuronalcellchronicneurologicalfunctionspinalcordinjurymotorInhibitorinhibitorinhibit

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