DBCO-PEG4-Val-Cit-PAB-PNP
Based on 1 Customer Validation
DBCO-PEG4-Val-Cit-PAB-PNP is a linker. DBCO-PEG4-Val-Cit-PAB-PNP conjugates anti-SYT2 monoclonal antibody with MALAT1 gapmer antisense oligonucleotides without inhibiting ASO activity or impairing the binding efficiency of the antibody to SYT2 antigen.
For research use only. We do not sell to patients.
- Purity: 97.27%
- CAS No.: 2226472-28-0
- Formula: C55H66N8O15
- Molecular Weight:1079.16
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-20336
Mc-Val-Cit-PABC-PNP
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HY-15575
VcMMAE
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-78738
MC-Val-Cit-PAB
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HY-19318
Fmoc-Val-Cit-PAB
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HY-141142
Boc-Val-Cit-PAB-PNP
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HY-140145
Mal-PEG4-Val-Cit-PAB-PNP
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HY-136314
DBCO-PEG4-VC-PAB-MMAE
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HY-141141
Boc-Val-Cit-PAB
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HY-140150
Azido-PEG3-Val-Cit-PAB-PNP
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HY-15575G
VcMMAE (GMP)
All Antibody-Oligonucleotide Conjugates (AOCs) Isoforms
More
Biological Activity
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AOC Linkers |
DBCO-PEG4-Val-Cit-PAB-PNP preserves MALAT1 ASO activity and PL13 binding to SYT2, enabling efficient antibody-oligonucleotide conjugate formation with ~80% conjugation efficiency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (5-8-week-old female)[1]
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Dosage:5 mg/kg
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Administration:i.v.; single injection
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Result:Reduced Malat1 RNA expression to 0.327, representing a 73.4% knockdown compared with PL13-positive cells from mice injected with PL13-randomized ASOs.
Decreased Malat1 RNA expression by 60.4% compared with PL13-negative cells from the same injected mice.
Chemical Information
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CAS No. 2226472-28-0
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Appearance Solid
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Molecular Weight 1079.16
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Formula C55H66N8O15
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SMILES
O=C(OC1=CC=C(C=C1)[N+]([O-])=O)OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (46.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9266 mL | 4.6332 mL | 9.2665 mL | 23.1662 mL |
| 5 mM | 0.1853 mL | 0.9266 mL | 1.8533 mL | 4.6332 mL | |
| 10 mM | 0.0927 mL | 0.4633 mL | 0.9266 mL | 2.3166 mL | |
| 15 mM | 0.0618 mL | 0.3089 mL | 0.6178 mL | 1.5444 mL | |
| 20 mM | 0.0463 mL | 0.2317 mL | 0.4633 mL | 1.1583 mL | |
| 25 mM | 0.0371 mL | 0.1853 mL | 0.3707 mL | 0.9266 mL | |
| 30 mM | 0.0309 mL | 0.1544 mL | 0.3089 mL | 0.7722 mL | |
| 40 mM | 0.0232 mL | 0.1158 mL | 0.2317 mL | 0.5792 mL |
DBCO-PEG4-Val-Cit-PAB-PNP Related Classifications
HY-W190913 Related Classifications
Powered by Bioz
- DBCO-PEG4-Val-Cit-PAB-PNP
- 2226472-28-0
- Antibody-Oligonucleotide Conjugates (AOCs)
- Biochemical Assay Reagents
- valine-citrulline linker
- mice
- MALAT1 ASO
- anti-SYT2 monoclonal antibodies
- MALAT1 gapmer antisense oligonucleotides
- human iPSC-derived MNs
- motor neurons
- SYT2 antigen
- spinal cord cells
- PL13
- Inhibitor
- inhibitor
- inhibit