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Cat. No.: HY-185493

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Mal-VC-PAB-seco-CBI-PBD dimer

Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 1661823-95-5
Formula: C₆₀H₇₂ClN₉O₁₁
Molecular Weight:1130.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mal-VC-PAB-seco-CBI-PBD dimer Chemical Structure

CAS No.: 1661823-95-5

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Biological Activity
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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

ADCs containing Mal-VC-PAB-seco-CBI-PBD dimer induce antigen-dependent cytotoxicity, inhibiting growth and causing death in HER2-positive and CD22-positive cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1661823-95-5
Molecular Weight 1130.72
Formula C₆₀H₇₂ClN₉O₁₁
SMILES

ClC[C@H]1C2=C(C=C(C3=CC=CC=C32)OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)N(C1)C(CCCCCOC6=C(C=C7C(N=C[C@@]8([H])N(CCC8)C7=O)=C6)OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yao HP, et al. Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021;26(8):1857-1874. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Mal-VC-PAB-seco-CBI-PBD dimer

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mal-VC-PAB-seco-CBI-PBD dimer Related Classifications

HY-185493 Related Classifications