1661823-95-5
Chemical Structure
Mal-VC-PAB-seco-CBI-PBD dimer
- CAS No.: 1661823-95-5
- Formula:C60H72ClN9O11
- Molecular Weight:1130.72
InChIKey: FOMPOPKSKACINN-YXGUXTIASA-N
SMILES: ClC[C@H]1C2=C(C=C(C3=CC=CC=C32)OCC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)N(C1)C(CCCCCOC6=C(C=C7C(N=C[C@@]8([H])N(CCC8)C7=O)=C6)OC)=O
Biological Activity: Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research[1].
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Mal-VC-PAB-seco-CBI-PBD dimer | Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research. | |||||||||||||||||||||
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Keywords
