NB-216
NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM). NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM). NB-216 can be used for the study of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 943924-04-7
- Formula: C35H45N3O4
- Molecular Weight:571.75
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Cathepsin Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
BACE1 17 nM (IC50) |
Cathepsin D 1 nM (IC50) |
Cathepsin E 0.4 nM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
20 nM
Compound: 3, NB-216
|
Inhibition of BACE1 expressed in APP-overexpressing CHO cells
Inhibition of BACE1 expressed in APP-overexpressing CHO cells
|
[PMID: 19963375] |
In Vitro
NB-216 (Compound 3) exhibits good passive permeability and low P-gP-mediated efflux, suggesting its potential to improve brain permeability in Madin-Darby canine kidney cells overexpressing the human form of P-glycoprotein (MDR1-MDCK)[1].
NB-216 exhibits an IC50 value of 20 nM in CHO cells overexpressing human amyloid precursor protein (APP)sup>[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 943924-04-7
-
Molecular Weight 571.75
-
Formula C35H45N3O4
-
SMILES
O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
-
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NB-216 Related Classifications
HY-11014 Related Classifications
Powered by Bioz