943924-04-7
Chemical Structure
NB-216
- CAS No.: 943924-04-7
- Formula:C35H45N3O4
- Molecular Weight:571.75
IUPAC Name: (S)-4-((R)-1-hydroxy-2-((1-(3-isopropylphenyl)cyclopropyl)amino)ethyl)-15-(methoxymethyl)-7-oxa-3,12-diaza-1,6(1,3)-dibenzenacyclododecaphan-2-one
InChIKey: GCZHKZTYTMTFGU-JHOUSYSJSA-N
SMILES: O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5
Biological Activity: NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM). NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM). NB-216 can be used for the study of Alzheimer's disease[1].
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NB-216 | NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM). NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM). NB-216 can be used for the study of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
