AcLys-PABC-VC-Aur0101 intermediate-1

Cat. No.: HY-48668: FAQs
Data Sheet Handling Instructions

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AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate.

For research use only. We do not sell to patients.

AcLys-PABC-VC-Aur0101 intermediate-1 Chemical Structure

CAS No. : 1609108-48-6

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Purity & Documentation
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Description

AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate^[1].

IC₅₀ & Target^[1]

Cleavable Linker

Molecular Weight

771.90

Formula

C₄₁H₅₃N₇O₈

CAS No.

1609108-48-6

SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (129.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2955 mL	6.4775 mL	12.9550 mL
5 mM	0.2591 mL	1.2955 mL	2.5910 mL
10 mM	0.1296 mL	0.6478 mL	1.2955 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2955 mL	6.4775 mL	12.9550 mL	32.3876 mL
	5 mM	0.2591 mL	1.2955 mL	2.5910 mL	6.4775 mL
	10 mM	0.1296 mL	0.6478 mL	1.2955 mL	3.2388 mL
	15 mM	0.0864 mL	0.4318 mL	0.8637 mL	2.1592 mL
	20 mM	0.0648 mL	0.3239 mL	0.6478 mL	1.6194 mL
	25 mM	0.0518 mL	0.2591 mL	0.5182 mL	1.2955 mL
	30 mM	0.0432 mL	0.2159 mL	0.4318 mL	1.0796 mL
	40 mM	0.0324 mL	0.1619 mL	0.3239 mL	0.8097 mL
	50 mM	0.0259 mL	0.1296 mL	0.2591 mL	0.6478 mL
	60 mM	0.0216 mL	0.1080 mL	0.2159 mL	0.5398 mL
	80 mM	0.0162 mL	0.0810 mL	0.1619 mL	0.4048 mL
	100 mM	0.0130 mL	0.0648 mL	0.1296 mL	0.3239 mL