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Cat. No.: HY-N10109

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Gallinamide A

Gallinamide A is a potent inhibitor of cathepsin L with an IC₅₀ value of 17.6 pM.

For research use only. We do not sell to patients.

CAS No.: 1208232-55-6
Formula: C₃₁H₅₂N₄O₇
Molecular Weight:592.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Gallinamide A Chemical Structure

CAS No.: 1208232-55-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Gallinamide A is a potent inhibitor of cathepsin L with an IC₅₀ value of 17.6 pM.

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	34.6 μM Compound: 1	Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay	[PMID: 30006166]
A-375	IC₅₀	45.6 μM Compound: 1	Antiproliferative activity against human A375 cells after 48 hrs by MTT assay Antiproliferative activity against human A375 cells after 48 hrs by MTT assay	[PMID: 30006166]
A549	IC₅₀	40.4 μM Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30006166]
B16-F10	IC₅₀	59.7 μM Compound: 1	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 30006166]
HeLa	IC₅₀	12 μM Compound: 1	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 30006166]
HT-29	IC₅₀	53 μM Compound: 1	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 30006166]
MCF7	IC₅₀	45.5 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30006166]
MDA-MB-231	IC₅₀	34.9 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 30006166]
PANC-1	IC₅₀	31.2 μM Compound: 1	Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay	[PMID: 30006166]
Vero C1008	CC₅₀	>100 μM Compound: 1; GalA	Cytotoxicity against cells African green monkey Vero E6 cells incubated for 24 to 72 hrs by alamar blue assay Cytotoxicity against cells African green monkey Vero E6 cells incubated for 24 to 72 hrs by alamar blue assay	[PMID: 34730959]
Vero C1008	CC₅₀	0.088 μM Compound: Gallinamide A	Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 37229831]
Vero C1008	EC₅₀	0.028 μM Compound: Gallinamide A	Antiviral activity against SARS-COV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral growth Antiviral activity against SARS-COV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral growth	[PMID: 37229831]

Chemical Information

CAS No. 1208232-55-6
Molecular Weight 592.77
Formula C₃₁H₅₂N₄O₇
SMILES

CC[C@H](C)[C@H](N(C)C)C(O[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)/C=C/C(N1[C@H](C(OC)=CC1=O)C)=O)=O)=O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
marine cyanobacterium?Schizothrix?sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ashhurst AS, et al. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv [Preprint]. 2020 Dec 24:2020.12.23.424111. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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