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Results for "

HeLa+cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (2) ADC Payload (2) Akt (4) Amino Acid Derivatives (1) AMPK (2) Antibiotic (16) Apoptosis (41) Atg8/LC3 (2) Aurora Kinase (2) AUTACs (4) Autophagy (18) Bacterial (22) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Myc (1) CaMK (2) Caspase (7) CDK (1) Complement System (1) Cytochrome P450 (1) Dengue Virus (1) Deubiquitinase (1) DNA/RNA Synthesis (3) Drug Derivative (3) Drug Intermediate (4) Drug Metabolite (1) DYRK (2) EGFR (5) Endogenous Metabolite (9) Environmental Pollutants (4) Epigenetic Reader Domain (2) ERK (2) Fat Mass and Obesity-associated Protein (FTO) (1) Filovirus (2) Fluorescent Dye (4) Fungal (6) G-quadruplex (1) Glyoxalase (GLO) (1) HDAC (4) Heme Oxygenase (HO) (2) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (5) Histone Demethylase (1) HIV (1) HSP (5) HSV (1) Huntingtin (1) Indoleamine 2,3-Dioxygenase (IDO) (8) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (6) JAK (1) Kinesin (1) KLF (1) Ligands for E3 Ligase (2) Lipoxygenase (1) LPL Receptor (2) LYTACs (1) MDM-2/p53 (1) MEK (1) MicroRNA (3) Microtubule/Tubulin (14) MMP (1) MOFs (1) Monocarboxylate Transporter (1) mTOR (1) MyD88 (2) Necroptosis (1) NEKs (1) NF-κB (3) NO Synthase (2) P-glycoprotein (3) P2Y Receptor (1) p38 MAPK (4) Parasite (12) PARP (2) PERK (1) Phosphatase (5) Phosphodiesterase (PDE) (3) Photosensitizer (2) PI3K (3) Polo-like Kinase (PLK) (2) Porcupine (1) PROTACs (10) Proteasome (2) Ras (2) Reactive Oxygen Species (ROS) (6) Reference Standards (12) Reverse Transcriptase (1) RSV (2) SARS-CoV (1) Ser/Thr Protease (2) SHP2 (3) Sirtuin (2) SOS1 (1) Src (1) STAT (11) SWI/SNF Complex (1) Tau Protein (1) Telomerase (2) TNF Receptor (1) Toll-like Receptor (TLR) (2) Topoisomerase (1) TSPO (1) VEGFR (2) Wnt (1) α-synuclein (1)
By Research Areas:	Cancer (183) Cardiovascular Disease (2) Infection (41) Inflammation/Immunology (13) Metabolic Disease (5) Neurological Disease (10)
Oligonucleotides:	Guanine Nucleotide (1) Nucleotide Analogs (1) Aptamers (1) Cationic Lipids (1) Antisense Oligonucleotides (2)

210

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12053A

Vinorelbine ditartrate Maximum Cited Publications 21 Publications Verification KW-2307; Nor-5'-anhydrovinblastine ditartrate	Microtubule/Tubulin Autophagy	Neurological Disease Cancer
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-10225

Belinostat 30+ Cited Publications PXD101; PX105684	HDAC Autophagy	Cancer
Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC₅₀ of 27 nM in HeLa cell extracts.

HY-100947

VH-298 15+ Cited Publications	Ligands for E3 Ligase HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology Cancer
VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a K_d value of 80 to 90 nM. VH-298 leads to HIF-α accumulation inside HeLa cells. VH-298 is an E3 ligase Ligand, and can be used for synthesis of PROTACs .

HY-N0144

Piperine 15+ Cited Publications Bioperine; 1-Piperoylpiperidine	Environmental Pollutants Endogenous Metabolite Autophagy P-glycoprotein	Inflammation/Immunology Cancer
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-122571

Retro-2 2 Publications Verification	Filovirus Parasite Autophagy	Infection Cancer
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC₅₀ of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy .

HY-112716

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 1 Publications Verification	Amino Acid Derivatives	Cancer
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

HY-N8015

Octanal 1 Publications Verification	Environmental Pollutants Endogenous Metabolite Fungal Bacterial	Infection Cancer
Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-100771

PCC0208009	Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease
PCC0208009 is a potent IDO inhibitor with an IC₅₀ value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .

HY-119401

CAY10444 4 Publications Verification BML-241	LPL Receptor	Cancer
CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca²⁺ in HeLa cells expressing S1P3 receptors .

HY-12053

Vinorelbine KW-2307 base	Microtubule/Tubulin Autophagy	Cancer
Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-18399

YM-1 1 Publications Verification	HSP NO Synthase	Cancer
YM-1 is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins .

HY-100541

INH6	NEKs Apoptosis	Cancer
INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC₅₀ of 2.4 μM.

HY-103349

PETCM 1 Publications Verification	Caspase Apoptosis	Cancer
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	ADC Payload	Cancer
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-162655

SLF80821178 1 Publications Verification	LPL Receptor	Neurological Disease
SLF80821178 is a potent and orally active inhibitor of Sphingosine-1-Phosphate Transporter (Spns2). SLF80821178 inhibits S1P release with an IC₅₀ of 51 nM in HeLa cells and a T_1/2 of 2.4 h in mouse .

HY-100853

IWP-O1	Porcupine Wnt	Cancer
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC₅₀ of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells .

HY-169794

N-Palmitoyl-phenylalanine	DNA/RNA Synthesis	Others
N-Palmitoyl-phenylalanine is an N-acyl amide that contains the long-chain saturated fatty acid Palmitic acid (HY-N0830) conjugated via an amide bond to the essential amino acid L-Phenylalanine (HY-N0215). N-Palmitoyl-phenylalanine inhibits pre-mRNA splicing in HeLa cell nuclear lysates (IC₅₀ ＞ 400 μM) but has no splicing activity in intact HeLa cells .

HY-N4208

Taccalonolide AJ 1 Publications Verification	Microtubule/Tubulin	Cancer
Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC₅₀ of 4.2 nM for HeLa cells .

HY-170944

BAG3/HSP70-IN-1	HSP Apoptosis Caspase	Cancer
BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with K_ds of 33.10 μM, 27.90 μM, and 33.80 μM, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC₅₀ of 49.46 μM. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity .

HY-137498

EBOV/MARV-IN-1	Filovirus	Infection
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC₅₀=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells .

HY-139290A

RGLS4326 sodium 2 Publications Verification RG4326 sodium	MicroRNA	Cancer
RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 sodium can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 sodium inhibits miR-17 function in HeLa cells with an EC₅₀ value of 28.3 nM .

HY-N0144R

Piperine (Standard) Bioperine (Standard); 1-Piperoylpiperidine (Standard)	Reference Standards P-glycoprotein Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-123554

Flavagline FL3	Apoptosis	Cancer
Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus .

HY-122751

(R)-DNMDP	Phosphodiesterase (PDE)	Cancer
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC₅₀ compared to the (S)-enantiomer in HeLa cell line .

HY-N8228

17-Hydroxyneomatrine	Bacterial	Infection Inflammation/Immunology Cancer
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-N7654

(-)-Epipodophyllotoxin	Apoptosis	Cancer
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI₅₀s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro .

HY-174215

TAU-IN-3	Tau Protein	Neurological Disease
TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases .

HY-103394

TC HSD 21	17β-HSD	Cancer
TC HSD 21 is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) against related 17β-HSD isozymes, with an IC₅₀ of 14 nM in HeLa cells. TC HSD 21 can be used in the research of prostate cancer .

HY-144712

L5-DA	G-quadruplex Apoptosis	Cancer
L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC₅₀=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .

HY-N4062

Hedychenone	Others	Others
Hedychenone (compound 3) is a labdane diterpene. Hedychenone can be isolated from the rhizomes of Hedychium yunnanense. Hedychenone against HeLa cell with IC₅₀ value of 9.76 μg/ml.

HY-131871

Ethyl LipotF	Fat Mass and Obesity-associated Protein (FTO)	Cancer
Ethyl LipotF is a selective FTO inhibitor that significant increases modified N6-methyladenosine (m6A) levels in HeLa cells in a concentration-dependent manner .

HY-150409

TSPO ligand-2	TSPO	Cancer
TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells .

HY-161771

JNJ-7184	RSV	Infection
JNJ-7184 is a non-nucleoside inhibitor of the RSV-Large (L) polymerase, with the pEC₅₀ and pCC₅₀ of 7.86 and 4.29 in Hela cells, respectively. JNJ-7184 prevents RSV replication and transcription by inhibiting initiation or early elongation .

HY-N4048

Heudelotinone	Others	Cancer
Heudelotinone is a dinorditerpenoid that can be isolated from the stem bark and roots of Ricinodendron heudelotii. Heudelotinone shows cytotoxicity against SMMC-7721, A549 and Hela cells with IC₅₀s of 21.68, 16.04 and 10.67 μM, respectively .

HY-N10871

Neocryptomerin	SARS-CoV	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell. Neocryptomerin has favorable binding affinities in the active pocket of SARS-CoV-2. Neocryptomerin is the leading compound of rational compounds against COVID-19 .

HY-175175

MAPK-IN-5	p38 MAPK Bcl-2 Family Caspase Reactive Oxygen Species (ROS) PARP Apoptosis	Cancer
MAPK-IN-5 is a potent MAPK inhibitor with an IC₅₀ of 1.35 μM against HeLa cells. MAPK-IN-5 inhibits HeLa cell proliferation by inducing ROS-mediated DNA damage and mitochondrial apoptosis via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation, reduces the number of live cells, suppresses cell migration, and causes cell cycle arrest in the G2/M phase in HeLa cells. MAPK-IN-5 can be used for the study of cervical cancer .

HY-12053AS

Vinorelbine-d3 ditartrate 2 Publications Verification KW-2307-d3 ditartrate; Nor-5'-anhydrovinblastine-d3 ditartrate	Microtubule/Tubulin Autophagy	Cancer
Vinorelbine-d₃ (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

HY-128599

NMS-P515	PARP	Cancer
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a K_d of 16 nM and an IC₅₀ of 27 nM (in Hela cells). Anti-tumor activity .

HY-123583

MitoBADY	Fluorescent Dye	Others
MitoBADY is a mitochondria-selective Raman probe that successfully visualizes mitochondria in live HeLa cells at a concentration of 200-400 nM for 10 minutes. MitoBADY can be utilized for the study of mitochondrial dynamics .

HY-N11636

Ganoderic acid S	Apoptosis	Cancer
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .

HY-131822

5'-UMPS Uridine-5'-O-monophosphorothioate	P2Y Receptor	Cancer
5'-UMPS (Uridine-5'-O-monophosphorothioate) is a P2Y14 receptor agonist. 5'-UMPS can induce HeLa cell growth slightly .

HY-N12233

Condurango glycoside A	Apoptosis MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-150655

Hsp90-IN-15	HSP	Cancer
Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell .

HY-N3191

N-trans-Feruloyl-3-methyldopamine	Others	Others
N-trans-Feruloyl-3-methyldopamine (compound 4) is an anticancer compound isolated from Alternanthera philoxeroides. N-trans-Feruloyl-3-methyldopamine is cytotoxic to HeLa cells, with an inhibition rate of 72.2% at a concentration of 30 μg/mL .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Apoptosis Caspase Parasite	Infection Cancer
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-18406

YM-1 tosylate	HSP	Cancer
YM-1 tosylate is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 tosylate induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins .

HY-147896

Tubulin polymerization-IN-29	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-29 (compound 6g) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-29 exhibits potent antiproliferative activity. Tubulin polymerization-IN-29 can induce HeLa cells arrest in G2/M phase .

HY-W654320

Piperin-d10 Bioperine-d₁₀; 1-Piperoylpiperidine-d₁₀	Isotope-Labeled Compounds Endogenous Metabolite P-glycoprotein Autophagy	Cancer
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-130073

Amorfrutin A	NF-κB Apoptosis	Cancer
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-137949

Formoxanthone A	Apoptosis	Cancer
Formoxanthone A is an apoptosis inducing compound that can significantly reduce the viability of HeLa cells at 25 μM .

Cat. No.	Product Name	Type

HY-D1422

ER Tracker Yellow

BDNCA-346

Fluorescent Dyes

ER Tracker Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe. ER Tracker Yellow has high temperature sensitivity (3.9%/°C) and is not affected by pH and Ca ²⁺ interference. ER Tracker Yellow can be used for real-time monitoring of local temperature changes in the ER area. ER Tracker Yellow maintains its function in fixed cells. ER Tracker Yellow is suitable for various cell lines and primary cells, such as HeLa cells, MEF cells, and other cells .

HY-D2215

Mito-CCY	Fluorescent Dyes
Mito-CCY is a mitochondria-targeted, NIR-absorbing cryptocyanine probe. Mito-CCY displays a high photothermal conversion efficiency, good biological compatibility in vitro, and photoinduced cytotoxicity in HeLa cells .

HY-D2360

O-Carboranylphenoxyacetanilide	Fluorescent Dyes
O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC₅₀: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity .

HY-B0497G

Niclosamide

BAY2353

Fluorescent Dyes

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-160065F

FAM-sgc8c aptamer sodium	Fluorescent Dyes
FAM-sgc8c aptamer sodium is a 5-FAM labeled sgc8c aptamer sodium (HY-160065). sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of FAM-sgc8c aptamer sodium to PTK-7 induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals .

Cat. No.	Product Name	Type

HY-112624E

Dextran T0.8 (MW 800)

Dextran 0.8; Dextran D0.8; Dextran T0.8(MW 640-960)

Biochemical Assay Reagents

Dextran T0.8 (Dextran 0.8; Dextran T0.8(MW 640-960)) is a food additive with a porous network structure that exhibits strong hydration capacity and low browning activity. Dextran T0.8 (MW 800) can improve the coagulation of dairy products and is used as a prebiotic in baked goods. Dextran T0.8 (MW 800) is non-toxic to HeLa cells at a concentration of ~500 μg/mL and has a low relative browning rate in the Maillard reaction. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-B0497G

Niclosamide

BAY2353

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

HY-204478

Ac-KVPL-CMK	Peptides	Cancer
Ac-KVPL-CMK is an inhibitor that specifically targets Granzyme M (GrM). Ac-KVPL-CMK significantly inhibits GrM-mediated tumor cell death. Ac-KVPL-CMK reduces the cytotoxic activity of LAK cells against HeLa cells. Ac-KVPL-CMK can be used for the study of cancer .

HY-204478A

Ac-KVPL-CMK TFA	Peptides	Cancer
Ac-KVPL-CMK TFA is the trifluoroacetic acid of Ac-KVPL-CMK (HY-204478). Ac-KVPL-CMK is an inhibitor that specifically targets Granzyme M (GrM). Ac-KVPL-CMK significantly inhibits GrM-mediated tumor cell death. Ac-KVPL-CMK reduces the cytotoxic activity of LAK cells against HeLa cells. Ac-KVPL-CMK can be used for the study of cancer .

HY-P5937

Caerin 1.1 TFA	Apoptosis	Cancer
Caerin 1.1 TFA is a host defense peptide isolated from the glandular secretions of the Australian tree frog Litoria. Caerin 1.1 TFA inhibits HeLa cell proliferation and mediates apoptosis. Caerin 1.1 TFA may enhance adaptive T cell immune responses .

HY-180989

PROTAC PLK1 Degrader-2	PROTACs Polo-like Kinase (PLK) Apoptosis	Cancer
PROTAC PLK1 Degrader-2 (Compound NC1) is a PLK1 PROTAC degrader with an K_d of 6.06 μM. PROTAC PLK1 Degrader-2 significantly inhibits the proliferation of HeLa cells, induces cell cycle arrest and apoptosis. PROTAC PLK1 Degrader-2 exhibits significant anti-tumor activity in a HeLa cell xenograft tumor mouse model. PROTAC PLK1 Degrader-2 can be used for the study of cervical cancer.

HY-P11657

GN-2 peptoid	Bacterial	Infection
GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12053A

Vinorelbine ditartrate Maximum Cited Publications 21 Publications Verification KW-2307; Nor-5'-anhydrovinblastine ditartrate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Microtubule/Tubulin Autophagy
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-N0144

Piperine 15+ Cited Publications Bioperine; 1-Piperoylpiperidine	Structural Classification Classification of Application Fields Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Autophagy P-glycoprotein
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-16558

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	Chalcones Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N8015

Octanal 1 Publications Verification	Infection Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Fungal Bacterial
Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-N12257

Antimycin A2 2 Publications Verification	Structural Classification Monophenols Microorganisms Phenols Source Classification	Cytochrome P450 Reactive Oxygen Species (ROS) Apoptosis
Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	Microorganisms Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	ADC Payload
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-N1464A

Aristolone	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification Cancer	Complement System Apoptosis
Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .

HY-W097625

6-Methoxyflavone	Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell. Source Classification	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO)
6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway in HeLa cells. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases .

HY-N0144R

Piperine (Standard) Bioperine (Standard); 1-Piperoylpiperidine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Source Classification	Reference Standards P-glycoprotein Autophagy Endogenous Metabolite
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N8228

17-Hydroxyneomatrine	Alkaloids Leguminosae Other Alkaloids Plants Sophora flavescens Aiton Source Classification	Bacterial
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-N7654

(-)-Epipodophyllotoxin	other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Cancer Source Classification	Apoptosis
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI₅₀s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro .

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation .

HY-N4062

Hedychenone	Terpenoids Diterpenoids Plants Source Classification Zingiberaceae Hedychium yunnanense Gagnep.	Others
Hedychenone (compound 3) is a labdane diterpene. Hedychenone can be isolated from the rhizomes of Hedychium yunnanense. Hedychenone against HeLa cell with IC₅₀ value of 9.76 μg/ml.

HY-N4048

Heudelotinone	Ricinodendron heudelotii (Baill.) Heckel Terpenoids Diterpenoids Euphorbiaceae Plants Source Classification	Others
Heudelotinone is a dinorditerpenoid that can be isolated from the stem bark and roots of Ricinodendron heudelotii. Heudelotinone shows cytotoxicity against SMMC-7721, A549 and Hela cells with IC₅₀s of 21.68, 16.04 and 10.67 μM, respectively .

HY-N10871

Neocryptomerin	Flavonoids Taxodiaceae Plants Cunninghamia lanceolata var. konishii Biflavones Source Classification	SARS-CoV
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell. Neocryptomerin has favorable binding affinities in the active pocket of SARS-CoV-2. Neocryptomerin is the leading compound of rational compounds against COVID-19 .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	Antibiotics Fissistigma balansae (A. DC.) Merr. Disease Research Plants Annonaceae Anticancer Other Antibiotics Source Classification	DYRK
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-125300

Oligomycin E	Natural Products Microorganisms Source Classification	Fungal Antibiotic
Oligomycin E is a antitumor antibiotic that can be isolated from Streptomyces. Oligomycin E has significant antifungal activity, showing minimal inhibitory concentrations (MICs) values between 2 and 75μg/mL. Oligomycin E has strong antitumor activity against HeLa cells, with an IC₅₀ of 0.014 μg/mL .

HY-119789

Albofungin	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Albofungin (Antibiotic P-42-1) is isolated from the culture filtrate of Actinomyces tumemacerans strain INMI.P-42. Albofungin shows highly active on a wide variety of gram-positive bacteria and fungi. Albofungin shows cytotoxic to HeLa cell cultures and exhibited antitumor activity on EHRLICH ascites tumor in mice.

HY-N8954

Kaempferol 7-O-neohesperidoside	Flavonols Flavonoids Litchi Chinensis Sonn. Sapindaceae Plants Source Classification	Others
Kaempferol 7-O-neohesperidoside is a ?avonoid glycoside that can be isolated from Litchi chinensis. Kaempferol 7-O-neohesperidoside exhibits significant cytotoxic activity against A549, LAC, Hep-G2, and HeLa cell lines with IC₅₀s of 0.53, 7.93, 0.020, and 0.051 μM, respectively .

HY-N11636

Ganoderic acid S	Triterpenes Microorganisms Terpenoids Source Classification	Apoptosis
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .

HY-N12233

Condurango glycoside A	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Plants Steroids Source Classification	Apoptosis MDM-2/p53 Reactive Oxygen Species (ROS)
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-N3191

N-trans-Feruloyl-3-methyldopamine	Phenols Polyphenols Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Source Classification	Others
N-trans-Feruloyl-3-methyldopamine (compound 4) is an anticancer compound isolated from Alternanthera philoxeroides. N-trans-Feruloyl-3-methyldopamine is cytotoxic to HeLa cells, with an inhibition rate of 72.2% at a concentration of 30 μg/mL .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Pongamia pinnata (L.) Pierre Terpenoids Sesquiterpenes Plants Compositae Source Classification	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-130073

Amorfrutin A	Simple Phenylpropanols Leguminosae Amorpha fruticosaL. Phenylpropanoids Plants Source Classification	NF-κB Apoptosis
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-77572R

7-Epi 10-desacetyl paclitaxel (Standard) 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)	Structural Classification Microorganisms Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd. Source Classification	ADC Payload Reference Standards
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-137949

Formoxanthone A	Flavonoids Guttiferae Garcinia paucinervis Chun et How Plants Other Flavonoids Source Classification	Apoptosis
Formoxanthone A is an apoptosis inducing compound that can significantly reduce the viability of HeLa cells at 25 μM .

HY-117125

Longifolin	Natural Products Actinodaphne acuminata (Blume) Meisn. Plants Lauraceae Source Classification	Others
Longifolin is an anticancer agent that exhibits significant cytotoxicity against HeLa cell lines (IC50: 0.21 μg/mL).

HY-125720

A-39183A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
A-39183A is an antibiotic that shows significant cytotoxicity to HeLa cells, with an IC₅₀ value of 1.8 μM .

HY-N2213

Matairesinol 4′-O-β-D-glucopyranoside	Monophenols Clematis chinensis Osbeck Classification of Application Fields Ranunculaceae Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Others
Matairesinol 4′-O-β-D-glucopyranoside displays cytotoxic activity against HeLa cell line with an IC₅₀ of 47.1 μM .

HY-114708

Ilicicolin B LL-Z 1272β	Monophenols Microorganisms Phenols Source Classification	Bacterial
Ilicicolin B (LL-Z 1272β) inhibits Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells is 0.3 μg/mL .

HY-12053AR

Vinorelbine ditartrate (Standard) KW-2307 (Standard); Nor-5'-anhydrovinblastine ditartrate (Standard)	Apocynaceae Alkaloids Structural Classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Microtubule/Tubulin Autophagy
Vinorelbine (ditartrate) (Standard) is the analytical standard of Vinorelbine (ditartrate). This product is intended for research and analytical applications. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-N8876

Paucinervin A	Natural Products Guttiferae Garcinia paucinervis Chun et How Plants Source Classification	Others
Paucinervin A (Compound 1) is a type of bittern. Paucinervin A inhibits the growth of HeLa cells (IC₅₀=29.5 μM). Paucinervin A is isolated from the natural Garcinia paucinervis .

HY-N7485

Gomisin K1 (-)-Gomisin K1	Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	Others
Gomisin K1 ((-)-Gomisin K1) is a lignan that exhibits anti-cancer activity. Gomisin K1 inhibits HeLa cell growth, with an IC₅₀ of 5.46 μM .

HY-129148

Ganoderic acid AM1 GAAM1	Triterpenes Microorganisms Terpenoids Source Classification	Others
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N14822

4-O-Demethyl-11-deoxydoxorubicin	Quinones Microorganisms Anthraquinones Source Classification	Antibiotic Bacterial
4-O-Demethyl-11-deoxydoxorubicin is an anthracycline antibiotic with antibacterial and antitumor activities. 4-O-Demethyl-11-deoxydoxorubicin is cytotoxic to Hela cells .

HY-N14571

Quinomycin B	Natural Products Microorganisms Source Classification	Bacterial
Quinomycin B has a strong effect on Gram-positive bacteria and HeLa cells, and also on some Gram-negative bacteria. Quinomycin B also has a protective effect on mice inoculated with poliovirus .

HY-N10332

Leptosphaerodione	Quinones Monophenols Microorganisms Classification of Application Fields Phenols Naphthalene Quinones Disease Research Fields Cancer Source Classification	Proteasome
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC₅₀ value of 3.2 μM. Anti-tumor agent .

HY-N12866

Monensin C	Microorganisms Ketones, Aldehydes, Acids Source Classification	Antibiotic Bacterial
Monensin C is an oxygen-containing heterocyclic polyether antibiotic. Monensin C has antibacterial, mycobacterial, fungal and protozoan activity, but it has a weaker effect on Gram-negative bacteria and has an inhibitory effect on HeLa cells .

HY-N15076

Herbimycin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Src Antibiotic Bacterial
Herbimycin B is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Herbimycin B has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells .

HY-N16671

Desacetylbufotalin Bufogenin B; Deacetylbufotalin	Structural Classification Animals Animal Venoms Steroids Source Classification	Others
Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC₅₀ = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer .

HY-N11643

Ganoderic acid Mk GA-Mk	Triterpenes Microorganisms Terpenoids Source Classification	Apoptosis Reactive Oxygen Species (ROS) MMP Caspase
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research .

HY-N7821

Aphidicolin 17-acetate Aphidicolin 17-monoacetate	Structural Classification Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses .

HY-N12255

COTC	Natural Products Microorganisms Source Classification	Glyoxalase (GLO)
COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC₅₀ = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model .

HY-N12137

Glycoside St-J	Triterpenes Anemone flaccida Fr. Schmidt Terpenoids Ranunculaceae Plants Source Classification	Others
Glycoside St-J (Compound 2) is a triterpenoid saponin. Glycoside St-J has antitumor activity and inhibits HeLa cell proliferation. Glycoside St-J Isolates from natural Anemone flaccida. Glycoside St-J can be used in the development of new anticancer agents .

HY-N7507

Sempervirine	Alkaloids Classification of Application Fields Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Cancer Source Classification	Others
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

HY-N15226

Butyrolactone Ia	Microorganisms Phenols Source Classification	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N15349

Nocapyrone Q	Natural Products Microorganisms Source Classification	Others
Nocapyrone Q is a polyketide compound discovered in the karst cave mold Streptomyces sp. FD-2-6. At a dose of 100 μM, Nocapyrone Q exhibits inhibitory activity against human hepatocellular carcinoma HepG2 cells and human cervical cancer HeLa cells. Nocapyrone Q holds potential for research in the field of cancer therapy .

HY-N8015R

Octanal (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards Endogenous Metabolite Bacterial Fungal
Octanal (Standard) is the analytical standard of Octanal. This product is intended for research and analytical applications. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Cardiacglycosides Plants Steroids Source Classification	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

Cat. No.	Product Name	Chemical Structure

HY-N8015S

Octanal-d16
Octanal-d₁₆ is the deuterium labeled Octanal. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL .

HY-B0497S1

Niclosamide-13C6
Niclosamide- ¹³C₆ is the ¹³C₆ labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

HY-12053AS

Vinorelbine-d3 ditartrate 2 Publications Verification
Vinorelbine-d₃ (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-B0497S2

Niclosamide-d3
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-N8015S2

Octanal-d4
Octanal-d₄ is deuterated labeled Octanal (HY-N8015). Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL .

HY-B0497BS

Niclosamide-13C6 monohydrate

Niclosamide- ¹³C₆ (monohydrate) is the ¹³C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-10225S

Belinostat-d5
Belinostat-d₅ (PXD101-d₅) is the deuterium labeled Belinostat (HY-10225). Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC₅₀ of 27 nM in HeLa cell extracts.

Cat. No.	Product Name		Classification

HY-139290

RGLS4326 2 Publications Verification RG4326		Antisense Oligonucleotides
RGLS4326 (RG4326) is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 inhibits miR-17 function in HeLa cells with an EC₅₀ value of 28.3 nM .

HY-169794

N-Palmitoyl-phenylalanine		Cationic Lipids
N-Palmitoyl-phenylalanine is an N-acyl amide that contains the long-chain saturated fatty acid Palmitic acid (HY-N0830) conjugated via an amide bond to the essential amino acid L-Phenylalanine (HY-N0215). N-Palmitoyl-phenylalanine inhibits pre-mRNA splicing in HeLa cell nuclear lysates (IC₅₀ ＞ 400 μM) but has no splicing activity in intact HeLa cells .

HY-139290A

RGLS4326 sodium 2 Publications Verification RG4326 sodium		Antisense Oligonucleotides
RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 sodium can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 sodium inhibits miR-17 function in HeLa cells with an EC₅₀ value of 28.3 nM .

HY-160065

sgc8c aptamer sodium		Aptamers
sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7, thus achieving specific recognition and labeling of target cells .

HY-171573

3′-Azido-2′,3′-dideoxy-GTP AZddGTP		Nucleotide Analogs Guanine Nucleotide
3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a K_i value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0497G

Niclosamide BAY2353	Antibiotic Parasite STAT	Cancer
Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

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