SMER10
SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect.
For research use only. We do not sell to patients.
- CAS No.: 221238-83-1
- Formula: C16H17N3O
- Molecular Weight:267.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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All α-synuclein Isoforms
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Biological Activity
Chemical Information
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CAS No. 221238-83-1
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Molecular Weight 267.33
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Formula C16H17N3O
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SMILES
O=C1C2=C(N=CN1N)C=3C=CC=CC3CC24CCCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMER10 Related Classifications
HY-165539 Related Classifications
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