221238-83-1
Chemical Structure
SMER10
- CAS No.: 221238-83-1
- Formula:C16H17N3O
- Molecular Weight:267.33
IUPAC Name: 3-amino-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one
InChIKey: VQMVFISLGPSWGO-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=CN1N)C=3C=CC=CC3CC24CCCC4
Biological Activity: SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect[1].
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SMER10 | SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntington's disease and the A53T α-synuclein protein associated with Parkinson's disease. SMER10 exerts neuroprotective effect. | |||||||||||||||||||||
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Keywords
