Flavagline FL3

Cat. No.: HY-123554 Purity: 99.90%: Data Sheet
COA

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Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus.

For research use only. We do not sell to patients.

Flavagline FL3 Chemical Structure

CAS No. : 1186012-80-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	5.8 nM Compound: 2, FL3	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HCT-116	IC₅₀	7.6 nM Compound: 1a	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-116	IC₅₀	< 1 nM Compound: 3	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-15	IC₅₀	1 nM Compound: 3	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HEK-293T	IC₅₀	22.4 nM Compound: FL3	Antiviral activity against CHIKV infected in HEK293T cells Antiviral activity against CHIKV infected in HEK293T cells	[PMID: 38394369]
HL-60	IC₅₀	3.8 nM Compound: 2, FL3	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HL-60	IC₅₀	4.5 nM Compound: 1a	Cytotoxicity against human HL60R cells after 72 hrs by MTS assay Cytotoxicity against human HL60R cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	5.5 nM Compound: 1a	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	< 1 nM Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
HepG2	IC₅₀	4 nM Compound: 3	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	15 nM Compound: 1a	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	2.4 nM Compound: 2, FL3	Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
KB	IC₅₀	< 1 nM Compound: 3	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	1 nM Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	< 1 nM Compound: 3	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
MDA-MB-231	IC₅₀	3.8 nM Compound: 1a	Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay	[PMID: 21142180]
MDA-MB-435	IC₅₀	8.7 nM Compound: 1a	Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay	[PMID: 21142180]
PC-3	IC₅₀	17 nM Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 21142180]
SK-OV-3	IC₅₀	8.5 nM Compound: 1a	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 21142180]
SW48	IC₅₀	10 nM Compound: 154; FL3	Anticancer activity against human SW48 cells assessed as cell growth inhibition Anticancer activity against human SW48 cells assessed as cell growth inhibition	[PMID: 33445154]

Molecular Weight

483.35

Formula

C₂₅H₂₃BrO₅

CAS No.

1186012-80-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1C[C@H]([C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)Br)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (206.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0689 mL	10.3445 mL	20.6889 mL
5 mM	0.4138 mL	2.0689 mL	4.1378 mL
10 mM	0.2069 mL	1.0344 mL	2.0689 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (262 KB) HNMR (279 KB) RP-HPLC (231 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Frédéric Thuaud, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009 Aug 27;52(16):5176-87. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0689 mL	10.3445 mL	20.6889 mL	51.7224 mL
	5 mM	0.4138 mL	2.0689 mL	4.1378 mL	10.3445 mL
	10 mM	0.2069 mL	1.0344 mL	2.0689 mL	5.1722 mL
	15 mM	0.1379 mL	0.6896 mL	1.3793 mL	3.4482 mL
	20 mM	0.1034 mL	0.5172 mL	1.0344 mL	2.5861 mL
	25 mM	0.0828 mL	0.4138 mL	0.8276 mL	2.0689 mL
	30 mM	0.0690 mL	0.3448 mL	0.6896 mL	1.7241 mL
	40 mM	0.0517 mL	0.2586 mL	0.5172 mL	1.2931 mL
	50 mM	0.0414 mL	0.2069 mL	0.4138 mL	1.0344 mL
	60 mM	0.0345 mL	0.1724 mL	0.3448 mL	0.8620 mL
	80 mM	0.0259 mL	0.1293 mL	0.2586 mL	0.6465 mL
	100 mM	0.0207 mL	0.1034 mL	0.2069 mL	0.5172 mL

Flavagline FL3 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flavagline FL31186012-80-5Flavagline FL 3Flavagline FL-3ApoptosiscytotoxicityapoptosisAIFcaspase-12Inhibitorinhibitorinhibit

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Flavagline FL3

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Flavagline FL3 Related Antibodies

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Complete Stock Solution Preparation Table

Flavagline FL3 Related Classifications

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