BAG3/HSP70-IN-1
BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with Kds of 33.10 μM, 27.90 μM, and 33.80 μM, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 μM. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity.
For research use only. We do not sell to patients.
- Formula: C28H39N7O4
- Molecular Weight:537.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase 3 |
Caspase-9 |
Chemical Information
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Molecular Weight 537.65
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Formula C28H39N7O4
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SMILES
O=C(NCCCC)C(C1=CNC(NC1=O)=O)N(CC(C)CC)C(CN2N=NC(C3=CC(C)=C(C)C=C3C)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAG3/HSP70-IN-1 Related Classifications
HY-170944 Related Classifications
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