1,1′-Disinomenine
Based on 1 Customer Validation
1,1′-Disinomenine is a morphinane alkaloid dimer that exists in the stems of Sinomenium acutum. 1,1′-Disinomenine induces cytotoxicity in cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 596-58-7
- Formula: C38H44N2O8
- Molecular Weight:656.76
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
71.83 μM
|
Cytotoxicity against human lung adenocarcinoma A549 cells by MTT assay.
Cytotoxicity against human lung adenocarcinoma A549 cells by MTT assay.
|
18081254 |
| HeLa | IC50 |
70.69 μM
|
Cytotoxicity against human cervical carcinoma HeLa cells by MTT assay.
Cytotoxicity against human cervical carcinoma HeLa cells by MTT assay.
|
18081254 |
In Vitro
1,1′-Disinomenine (compound 3) weakly inhibits the viability of A549 and HeLa cells with IC50 values of 71.83 μM and 70.69 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 596-58-7
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Appearance Solid
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Molecular Weight 656.76
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Formula C38H44N2O8
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Color White to off-white
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SMILES
OC1=C2C(C[C@H](N(C)CC3)[C@](C=C4OC)([H])[C@@]23CC4=O)=C(C5=CC(OC)=C(O)C6=C5C[C@H]7[C@]8([H])[C@@]6(CCN7C)CC(C(OC)=C8)=O)C=C1OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)