Morphinane alkaloid dimers from Sinomenium acutum

  • J Nat Prod. 2008 Jan;71(1):127-9. doi: 10.1021/np0704654.
Hui-Zi Jin  1 ,  Xiao-Ling Wang ,  Hong-Bing Wang ,  Yu-Bo Wang ,  Li-Ping Lin ,  Jian Ding ,  Guo-Wei Qin
Affiliations
  • 1. Shanghai Institute of Materia Medical, Chinese Academy of Sciences, People's Republic of China.
PMID: 18081254 DOI: 10.1021/np0704654
Abstract

Two new morphinane Alkaloid Dimers, 2,2'-disinomenine (1) and 7',8'-dihydro-1,1'-disinomenine (2), and known 1, 1'-disinomenine (3), were isolated from ethanol extracts of stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of Alkaloids 1-3 was determined by direct comparison of their CD spectra with the known alkaloid sinomenine. The isolated Alkaloids were tested for cytotoxicity against A549, P388, and HeLa cell lines, and 1 and 3 showed weak inhibition against A549 and Hela cells.

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