1. Others JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  2. Isotope-Labeled Compounds STAT Parasite Antibiotic
  3. Niclosamide-13C6

Niclosamide-13C6  (Synonyms: BAY2353-13C6)

Cat. No.: HY-B0497S1 Purity: ≥99.0%
COA Handling Instructions

Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

For research use only. We do not sell to patients.

Niclosamide-<sup>13</sup>C<sub>6</sub> Chemical Structure

Niclosamide-13C6 Chemical Structure

CAS No. : 1325808-64-7

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Based on 1 publication(s) in Google Scholar

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Description

Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

333.08

Formula

C713C6H8Cl2N2O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[13C]1=[13CH][13CH]=[13C]([N+]([O-])=O)[13CH]=[13C]1Cl)C2=CC(Cl)=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Niclosamide-13C6
Cat. No.:
HY-B0497S1
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