HI5
HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer.
For research use only. We do not sell to patients.
- CAS No.: 2411548-90-6
- Formula: C42H43N5O8
- Molecular Weight:745.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 70 nM in HeLa[1]
HI5 (0-10 μM; 72 hours) exhibits potent antiproliferative activity in HeLa, PC-3, A549 and HUVEC[1].
HI5 (0.1 and 0.5 μM; 24 hours) exhibits markedly disruption of microtubule organization in a concentration-dependent manner[1].
HI5 (0.5 μM; 24 hours) significantly up-regulates the expression level of Bax protein, while down-regulates the protein of Bcl-2, furthermore, markedly up-regulates the protein expressions of caspase-3 and PARP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, PC-3, A549 and HUVEC[1]
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Concentration:0-10 μM
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Incubation Time:72 hours
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Result:Exhibited potent antiproliferative activity in HeLa, PC-3, A549 and HUVEC with IC50s of 0.07 ± 0.005 μM, 0.46 ± 0.06 μM, 0.22 ± 0.10 μM, 1.52 ± 0.09 μM, respectively.
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Cell Line:HeLa[1]
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Concentration:0.1 and 0.5 μM
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Incubation Time:24 hours
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Result:Exhibited markedly disruption of microtubule organization in a concentration-dependent manner.
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Cell Line:HeLa[1]
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Concentration:0.5 μM
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Incubation Time:24 hours
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Result:Significantly up-regulated the expression level of Bax protein, while down-regulated the protein of Bcl-2, furthermore, markedly up-regulated the protein expressions of caspase-3 and PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (18-22 g, 5 week-old, injected with HeLa cells)[1]
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Dosage:15 and 30 mg/kg
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Administration:IV; daily, for 21 days
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Result:Significantly inhibited tumor growth at a dose-dependent manner with inhibitory rates of 50.73% and 65.76% at doses of 15 and 30 mg/kg, respectively.
Chemical Information
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CAS No. 2411548-90-6
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Molecular Weight 745.82
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Formula C42H43N5O8
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SMILES
NC(CC1=CN(C)C2=CC=CC=C12)C(OCCC3=CN(CC4=CC=CC(C(OC5=CC(/C=C\C6=CC(OC)=C(OC)C(OC)=C6)=CC=C5OC)=O)=C4)N=N3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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