2411548-90-6
Chemical Structure
HI5
- CAS No.: 2411548-90-6
- Formula:C42H43N5O8
- Molecular Weight:745.82
IUPAC Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl 3-((4-(2-((1-methyltryptophyl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)methyl)benzoate
InChIKey: ZXDJTIHUHXGWOK-YPKPFQOOSA-N
SMILES: NC(CC1=CN(C)C2=CC=CC=C12)C(OCCC3=CN(CC4=CC=CC(C(OC5=CC(/C=C\C6=CC(OC)=C(OC)C(OC)=C6)=CC=C5OC)=O)=C4)N=N3)=O
Biological Activity: HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer[1].
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HI5 | HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer. | |||||||||||||||||||||
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Keywords
