HSP70-IN-4

Cat. No.: HY-18406: FAQs
Data Sheet Handling Instructions

Molarity Calculator

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC₅₀ of 3.2 μM. HSP70-IN-4 is not BBB permeable.

For research use only. We do not sell to patients.

HSP70-IN-4 Chemical Structure

CAS No. : 1427450-47-2

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of HSP70-IN-4:

Other Forms of HSP70-IN-4:

YM-1 In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HSP Isoform Specific Products:

View All Isoforms

Biological Activity
Purity & Documentation
References
Customer Review

Description

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC₅₀ of 3.2 μM. HSP70-IN-4 is not BBB permeable^[1].

IC₅₀ & Target^[1]

HSP70

3.2 μM (IC₅₀)

In Vitro

HSP70-IN-4 (Compound YM-01; 50 μM) significantly enhances the binding of Hsp70 to a misfolded protein^[1].
HSP70-IN-4 (0-30 μM; 72 h) inhibits MDA-MB-231, MCF10A and MCF7 viability with EC₅₀s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM, respectively^[1].
HSP70-IN-4 is stable in water (at least 8 h at room temperature)^[1].
HSP70-IN-4 is rapidly metabolized (t_1/2 value of ∼2-4 min) in human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MCF7, MCF10A and MDA-MB-231
Concentration:	0-30 μM
Incubation Time:	72 h
Result:	Inhibited viability with EC₅₀s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM for MDA-MB-231, MCF10A and MCF7, respectively.

In Vivo

HSP70-IN-4 (Compound YM-01) cannot pass the blood-brain barrier^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 mice^[1]

Dosage:

20 mg/kg

Administration:

Intravenous injection (Pharmacokinetic Analysis)

Result:

Initial pharmacokinetics of HSP70-IN-4 (Compound YM-01; 20 mg/kg; i.v.)^[1]

hour	plasma (ng/mL)	brain (ng/g)	kidney (ng/g)
0.16	359	0	74378
1	324	0	63231

Molecular Weight

553.72

Formula

C₂₇H₂₇N₃O₄S₃

CAS No.

1427450-47-2

SMILES

CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](C)C=CC=C4)=O.[O-]S(=O)(C5=CC=C(C)C=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miyata Y, et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. [Content Brief]

HSP70-IN-4 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-41427450-47-2HSPHeat shock proteinsblood-brain barrierBBBMDA-MB-231MCF10AMCF7Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks