SHP2-IN-8
SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 °C. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells.
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- CAS No.: 1801692-60-3
- Formule: C17H21Cl2N5S
- Masse moléculaire:398.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KYSE-520 cell line | IC50 |
2.67 μM
Compound: 29
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Antiproliferative activity against human KYSE-520 cells
Antiproliferative activity against human KYSE-520 cells
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[PMID: 32910655] |
SHP2-IN-8 (compound TK-453) (0-100 μM; 48 hours) has moderate inhibitory effects on the proliferation of KYSE-70, Hela and THP-1 cells[1].
SHP2-IN-8 (0-30 μM; 24 hours) induces the apoptosis of Hela cells in a concentration-dependent manner[1].
SHP2-IN-8 (0-30 μM; 0-2 hour）concentration- and time-dependently inhibits the phosphorylation of AKT in Hela and KYSE-70 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela, KYSE-70, THP-1[1]
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Concentration:0, 1, 3, 10, 30 and 100 μM
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Incubation Time:48 hours
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Result:Showed moderate inhibitory effects on the proliferation of KYSE-70, Hela and THP-1 cells at the concentrations of 30 and 100 μM.
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Cell Line:Hela[1]
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Concentration:0, 10 and 30 μM
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Incubation Time:24 hours
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Result:Induced the apoptosis of Hela cells in a concentration-dependent manner.
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Cell Line:Hela and KYSE-70[1]
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Concentration:0, 0.3, 1, 3, 10 and 30 μM; or 10 μM
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Incubation Time:2 hours; or 0, 5, 10, 15, 30, 60, 120 min
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Result:Concentration- and time-dependently inhibited the phosphorylation of AKT in Hela and KYSE-70 cell lines.
Chemical Information
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CAS No. 1801692-60-3
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Masse moléculaire 398.35
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Formule C17H21Cl2N5S
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SMILES
NC1=NC(N2CCC(C)(CN)CC2)=CN=C1SC3=CC=CC(Cl)=C3Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHP2-IN-8 Related Classifications
HY-144396 Related Classifications
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