1801692-60-3
1801692-60-3
Chemical Structure
SHP2-IN-8
- CAS No.: 1801692-60-3
- Formula:C17H21Cl2N5S
- Molecular Weight:398.35
InChIKey: HFZSVNQUAOVFHI-UHFFFAOYSA-N
SMILES: NC1=NC(N2CCC(C)(CN)CC2)=CN=C1SC3=CC=CC(Cl)=C3Cl
Biological Activity: SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 °C. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1].
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SHP2-IN-8 | SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 °C. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells. | |||||||||||||||||||||
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