1. JAK/STAT Signaling
    Stem Cell/Wnt
    Anti-infection
  2. STAT
    Parasite
    Antibiotic
  3. Niclosamide olamine

Niclosamide olamine  (Synonyms: BAY2353 olamine)

Cat. No.: HY-B0497C
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Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.

For research use only. We do not sell to patients.

Niclosamide olamine Chemical Structure

Niclosamide olamine Chemical Structure

CAS No. : 1420-04-8

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Description

Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

In Vitro

Niclosamide olamine (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
Niclosamide olamine (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].
Niclosamide olamine (10 μM) treatment inhibits virus replication in Vero E6 cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: BD140A, SW-13 and NCI-H295R cells
Concentration: 0.6 nM-46 µM
Incubation Time:
Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

Cell Viability Assay[4]

Cell Line: Hela cells
Concentration: 0.05-5 μM
Incubation Time: 24 hours
Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

Cell Viability Assay[5]

Cell Line: Vero E6 cells
Concentration: 10 μM
Incubation Time: 2 days
Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
In Vivo

Niclosamide sodium (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
Dosage: 100 mg/kg, 200 mg/kg
Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
Clinical Trial
Molecular Weight

388.20

Formula

C15H15Cl2N3O5

CAS No.
SMILES

O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.NCCO

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Niclosamide olamine
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HY-B0497C
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